CHRDL2

Gene Symbol	CHRDL2
Entrez Gene	25884
Alt Symbol	BNF1, CHL2
Species	Human
Gene Type	protein-coding
Description	chordin-like 2
Other Description	breast tumor novel factor 1\|chordin-like protein 2\|chordin-related protein 2
Swissprots	Q6WN32 Q6WN30 A5PKU9 Q7Z5J3 Q6WN31 Q6WN34
Accessions	EAW74944 EAW74945 Q6WN34 AF332891 AAG50288 AK304519 BAG65323 AL047873 AL110168 CAB53666 AY163868 AAO31809 AY279090 AAQ19179 AY279091 AAQ19180 AY279092 AAQ19181 AY279093 AAQ19182 AY279094 AAQ19183 AY358522 AAQ88886 BC141564 AAI41565 BC142623 AAI42624 BC153100 AAI53101 BF437637 JN579714 AEV56635 NM_001278473 NP_001265402 NM_001304390 NP_001291319 NM_001304391 NP_001291320 NM_001304415 NP_001291344 NM_001304416 NP_001291345 NM_001304417 NP_001291346 NM_015424 NP_056239
Function	May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. {ECO:0000250, ECO:0000269\|PubMed:12853144, ECO:0000269\|PubMed:15094188}.
Subcellular Location	Isoform 5: Cytoplasm {ECO:0000305}.
Tissue Specificity	Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma. {ECO:0000269\|PubMed:12853144, ECO:0000269\|PubMed:14660436, ECO:0000269\|PubMed:15094188}.

CHRDL2 (S-18) - sc-70160 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CHRDL2 (S-18): sc-70160. Western blot analysis of CHRDL2 expression in DU 145 (A), Caki-1 (B), U-251-MG (C), NTERA-2 cl.D1 (D) and ES-2 (E) whole cell lysates and human testis tissue extract (F).

Anti-CHRDL2 antibody - ab198786 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of formalin fixed paraffin embedded human colon cancer labeling CHRDL2 with ab198786 at 1/30

Anti-CHRDL2 antibody - ab133852 from Abcam

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHRDL2 antibody (ab133852) at 1 µg/ml + HeLa cell lysate at 10 µg

Anti-CHRDL2 antibody - ab167279 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-CHRDL2 antibody (ab167279) at 1 µg/mlLane 1 : Transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse HRP at 1/2500 dilution

Anti-CHRDL2 Antibody (aa200-250) - LS-C77110 from LifeSpan Bioscience

Prices	$545.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CHRDL2 Antibody (aa143-192) - LS-C152121 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CHRDL2 Antibody (aa200-250) - LS-C287271 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human BNF1 by Western Blot. Sample: Whole cell lysate (50 ug) from DU145 cells. Antibody: Affinity purified rabbit anti-BNF1 antibody used at 3 ug/ml. Detection: Chemiluminescence with an exposure time of 1 minute.

Chordin-like 2/CHRDL2 Antibody - AF2448 from Novus Biologicals

Prices	$99.00, $329.00
Sizes	25 µg, 100 µg
Host	Goat
Clonality	Polyclonal

Chordin-like 2/CHRDL2 was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using 15 µg/mL Goat Anti-Human Chordin-like 2/CHRDL2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2448) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Chordin-like 2/CHRDL2 Antibody - NBP1-88560 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: CHRDL2 Antibody [NBP1-88560] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

Chordin-like 2/CHRDL2 Antibody (272905) - MAB24481 from Novus Biologicals

Prices	$249.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	272905

Chordin-like 2/CHRDL2 Antibody (272919) - MAB2448 from Novus Biologicals

Prices	$99.00, $249.00
Sizes	25 µg, 100 µg
Host	Mouse
Clonality	Monoclonal
Clone	272919

Chordin-like 2/CHRDL2 Antibody - NB100-2319 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Chordin-like 2/CHRDL2 Antibody [NB100-2319] - Whole cell lysate (50 ug) from DU145 cells. Antibody used at 3 ug/ml.

Chordin-like 2/CHRDL2 Antibody - H00025884-D01P from Novus Biologicals

Prices	$399.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: Chordin-like 2/CHRDL2 Antibody [H00025884-D01P] - Analysis of CHRDL2 expression in mouse testis.

Chordin-like 2/CHRDL2 Antibody - H00025884-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Western Blot: Chordin-like 2/CHRDL2 Antibody [H00025884-B01P] - Analysis of CHRDL2 expression in transfected 293T cell line by CHRDL2 polyclonal antibody. Lane 1: CHRDL2 transfected lysate(49.61 KDa). Lane 2: Non-transfected lysate.

Chordin-like 2/CHRDL2 Antibody [Biotin] - BAF2448 from Novus Biologicals

Prices	$390.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

CHRDL2 Polyclonal Antibody - bs-3860R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHRDL2 antibody produced in rabbit - SAB1410482 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-CHRDL2: <B>Cat. No. SAB1410482</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~49.6 kDa using CHRDL2 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-CHRDL2 antibody produced in mouse - SAB1409071 from Sigma-Aldrich

Prices	$347.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-CHRDL2: <B>Cat. No. SAB1409071</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~49.6 kDa using CHRDL2 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

CHRDL2 Antibody - N-terminal region (ARP66005_P050) - ARP66005_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CHRDL2 antibody - GTX121394 from GeneTex

Host	Rabbit
Clonality	Polyclonal

Anti -BNF1 (CHRDL2, CHL2, FKSG37, Breast Tumor Novel Factor 1, Chordin-like 2) - B2188-02 from USBiological Life Science

Host	Rabbit
Clonality	Polyclonal

Human Chordin-like 2/CHRDL2 Antibody - MAB24481 from R&D Systems

Prices	$99.00, $249.00
Sizes	25 µg, 100 µg
Host	Mouse
Clone	272905

Human Chordin-Like 2 MAb (Clone 272905), Mouse IgG1 - MAB24481-SP from R&D Systems

Host	Mouse
Clonality	Monoclonal
Clone	272905

Mouse Chordin-like 2/CHRDL2 Antibody - AF2520 from R&D Systems

Prices	$99.00, $359.00
Sizes	25 µg, 100 µg
Host	Goat

Mouse Chordin-Like 2 Affinity Purified Polyclonal Ab, Goat IgG - AF2520-SP from R&D Systems

Host	Goat
Clonality	Polyclonal

Search more