| Gene Symbol |
DAXX
|
| Entrez Gene |
1616
|
| Alt Symbol |
BING2, DAP6, EAP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
death-domain associated protein
|
| Other Description |
CENP-C binding protein|ETS1-associated protein 1|Fas-binding protein|death domain-associated protein 6|death-associated protein 6|fas death domain-associated protein
|
| Swissprots |
Q5STK9 F5ANJ6 O14747 Q9BWI3 Q9UER7 O15141 O15208 F5ANJ7 B4E1I3 F5H082
|
| Accessions |
CAB09986 CAB09989 EAX03722 EAX03723 EAX03724 Q9UER7 AA533586 AB209493 BAD92730 AF006041 AAB63043 AF015956 AAB66585 AF039136 AAB92671 AF050179 AAC39853 AF097742 AAC72843 AK223404 BAD97124 AK292187 BAF84876 AK303767 BAG64733 AK303854 BAG64795 AK309612 AK313034 BAG35867 BC000220 AAH00220 BC073776 BC109073 AAI09074 BC109074 AAI09075 BM997178 CR457085 CAG33366 DC345308 DC359186 EU446949 ABZ92478 HQ436528 AEC33235 HQ436529 AEC33236 XM_005248860 XP_005248917 XM_005275218 XP_005275275 XM_005275354 XP_005275411 NM_001141969 NP_001135441 NM_001141970 NP_001135442 NM_001254717 NP_001241646 NM_001350 NP_001341
|
| Function |
Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activatiopn of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination
|
| Subcellular Location |
Isoform gamma: Nucleus {ECO:0000269|PubMed:21482821}. Note=Diffuse nuclear distribution pattern and no comparable dot-like accumulation of isoform 1. {ECO:0000269|PubMed:21482821}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Amyotrophic lateral sclerosis (ALS), MAPK signaling pathway, Herpes simplex infection
|