GGT1

Gene Symbol	GGT1
Entrez Gene	2678
Alt Symbol	CD224, D22S672, D22S732, GGT, GGT 1, GTG
Species	Human
Gene Type	protein-coding
Description	gamma-glutamyltransferase 1
Other Description	gamma-glutamyltranspeptidase 1|glutathione hydrolase 1|leukotriene-C4 hydrolase
Swissprots	Q08247 Q14404 Q9UMK1 P19440 Q8TBS1
Accessions	CAA07266 CAA07485 CAA07486 CAA07487 CAA07536 P19440 AL832738 AU077341 BC025927 AAH25927 BC035341 BC065921 AAH65921 BC069326 AAH69326 BC069473 AAH69473 BC069504 AAH69504 BC128234 AAI28235 BC128238 AAI28239 BC128239 AAI28240 BM673976 BU157907 BU164348 CD625024 CR456494 CAG30380 CU013091 CAK54522 CU013379 CAK54821 DQ000492 DQ893412 ABM84338 DQ895950 ABM86876 HY003521 J04131 AAA52547 J05235 AAA35889 L20490 AAA02884 L20493 AAA02886 L20494 AAA02887 M24087 AAA35899 M24903 AAA52546 X60069 CAA42674 NM_013421 NP_038265 NM_013430 NP_038347 NM_001032364 NM_001032365 NM_005265 NM_001288833 NP_001275762
Function	Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive. {ECO:0000269|PubMed:20622017, ECO:0000269|PubMed:24047895, ECO:0000269|PubMed:7673200, ECO:0000269|PubMed:7759490, ECO:0000269|PubMed:8095045, ECO:0000269|PubMed:8827453}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:23682772, ECO:0000269|PubMed:8095045}; Single-pass type II membrane protein {ECO:0000269|PubMed:23682772, ECO:0000269|PubMed:8095045}.
Tissue Specificity	Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. Isoform 3 is lung-specific. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.
Top Pathways	Taurine and hypotaurine metabolism, Glutathione metabolism, Arachidonic acid metabolism, Cyanoamino acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse GGT1 / GGT ELISA Kit (Sandwich ELISA) - LS-F5899 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.137 ng/ml Range 1.56-100 ng/ml

Human GGT1 / GGT ELISA Kit (Sandwich ELISA) - LS-F4583 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 1.56 ng/ml Range 1.56-100 ng/ml

Rat GGT1 / GGT ELISA Kit (Sandwich ELISA) - LS-F11538 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 1.56 Range 1.56-100 ng/ml

Human GGT1 / GGT ELISA Kit (Sandwich ELISA) - LS-F11536 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 Range 1.56-100 ng/ml

Mouse GGT1 / GGT ELISA Kit (Sandwich ELISA) - LS-F11537 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 1.56-100 ng/ml

Human gGT1 ELISA Kit - abx151654 from Abbexa Category ELISA Kit Sensitivity 0.59 ng/ml Range 1.563 ng/ml - 100 ng/ml

Gamma glutamyl transpeptidase, GGT, Human, ELISA Kit - CSB-EL009394HU from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Gamma-Glutamyltransferase 1 (gGT1), Human, ELISA Kit - SEB375Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.59ng/mL Range 1.56-100ng/mL

Gamma-glutamyltranspeptidase 1, GGT1, Human, ELISA Kit - E1375h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.78-50 ng/mL

Gamma Glutamyltransferase 1, yGT1, Human, ELISA Kit - E-EL-H1012 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.938 Range 1.563-100ng/mL

Gamma Glutamyltransferase 1, gGT1, Mouse, ELISA Kit - E-EL-M0536 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

GGT1 (Human) IP-WB Antibody Pair - H00002678-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

GGT1 (Human) Matched Antibody Pair - H00002678-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human gGT1 ELISA Kit - HG0167 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine gGT1 ELISA Kit - AG0167 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Gamma-glutamyltranspeptidase 1, ELISA Kit - MBS281653 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Gamma Glutamyltransferase 1, ELISA Kit - MBS045056 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 U/L. Range 6.25 U/L - 200 U/L.

Gamma Glutamyltransferase 1, ELISA Kit - MBS722692 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Gamma Glutamyltransferase 1, ELISA Kit - MBS057358 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Gamma Glutamyltransferase 1, ELISA Kit - MBS025619 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Gamma Glutamyltransferase 1, ELISA Kit - MBS067092 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Gamma Glutamyltransferase 1, ELISA Kit - MBS733463 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Gamma Glutamyltransferase 1, ELISA Kit - MBS025369 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 1.56ng/ml-50ng/ml.

Gamma Glutamyltransferase 1, ELISA Kit - MBS739358 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Gamma Glutamyltransferase 1, ELISA Kit - MBS017446 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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