| Gene Symbol |
Nnt
|
| Entrez Gene |
18115
|
| Alt Symbol |
4930423F13Rik, AI323702, BB168308
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
nicotinamide nucleotide transhydrogenase
|
| Other Description |
NAD(P) transhydrogenase, mitochondrial|pyridine nucleotide transhydrogenase
|
| Swissprots |
Q61941 Q9JK70
|
| Accessions |
AAF72982 EDL18349 EDL18350 EDL18351 EDL18352 EDL18353 Q61941 AK033282 BAC28219 AK040460 BAC30596 AK050478 AK052061 AK052234 BAC34893 AK054332 BAC35734 AK079497 AK083413 AK084546 BAC39215 AK084604 BAC39226 AK085260 AK085903 BAC39564 AK087064 BAC39793 AK088044 BAC40113 AK090115 BAC41101 AK129006 AK159694 BAE35294 AK168736 BAE40577 AK180495 AK192828 AK198291 BC008518 AAH08518 BP768059 BY078900 BY093825 CJ192946 Z49204 CAA89065 NM_001308506 NP_001295435 NM_008710 NP_032736 NR_003544
|
| Function |
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues. {ECO:0000269|PubMed:22634753}.
|
| Top Pathways |
Nicotinate and nicotinamide metabolism
|