CYP8B1

Gene Symbol	CYP8B1
Entrez Gene	1582
Alt Symbol	CP8B, CYP12
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 8, subfamily B, polypeptide 1
Other Description	7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase|CYPVIIIB1|cytochrome P450 8B1|cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1|sterol 12-alpha-hydroxylase
Swissprots	O75958 Q6NWT3 Q9UNU6 Q6NWT2 B2RCY3
Accessions	AAD19877 EAW64682 Q9UNU6 AF090318 AAC63037 AK310784 AK315330 BAG37730 BC067434 AAH67434 BC067441 AAH67441 BC067442 AAH67442 BC067443 BC067444 AAH67444 NM_004391 NP_004382
Function	Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Tissue Specificity	Liver.
Top Pathways	Primary bile acid biosynthesis, PPAR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CYP8B1 CRISPR/Cas9 KO Plasmid (h) - sc-403383 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CYP8B1 HDR Plasmid (h) - sc-403383-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CYP8B1 Double Nickase Plasmid (h) - sc-403383-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CYP8B1 Double Nickase Plasmid (h2) - sc-403383-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CYP8B1 CRISPR Activation Plasmid (h) - sc-403383-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CYP8B1 CRISPR Activation Plasmid (h2) - sc-403383-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CYP8B1 Lentiviral Activation Particles (h) - sc-403383-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CYP8B1 Lentiviral Activation Particles (h2) - sc-403383-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CYP8B1 siRNA (h) - sc-41494 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CYP8B1 shRNA Plasmid (h) - sc-41494-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CYP8B1 shRNA (h) Lentiviral Particles - sc-41494-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CYP8B1 RNAi - H00001582-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU040681 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2215 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2215 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CYP8B1 siRNA (Human) - CRH1111 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CYP8B1 - MBS8211768 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CYP8B1 CRISPR/Cas9 KO Plasmid (h2) - sc-403383-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CYP8B1 HDR Plasmid (h2) - sc-403383-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human CYP8B1 (NM_004391.2) - SHH273809 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human CYP8B1(NM_004391.2) - SHG218131 from Creative biogene Category siRNA Species Reactivities Human

Human CYP8B1 siRNA - orb261613 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CYP8B1 shRNA Plasmid (Human) - CHH1111 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CYP8B1 miRNA 3'UTR clone - MiUTR1H-02645 from Creative biogene Species Reactivities Human

Search more