GLI1

Gene Symbol GLI1
Entrez Gene 2735
Alt Symbol GLI
Species Human
Gene Type protein-coding
Description GLI family zinc finger 1
Other Description GLI-Kruppel family member GLI1|glioma-associated oncogene 1|glioma-associated oncogene homolog 1 (zinc finger protein)|oncogene GLI|zinc finger protein GLI1
Swissprots F5H6H8 D0EUY3 Q8TDN9 E9PQQ9 P08151
Accessions AAM13391 BAN82437 EAW97013 P08151 AB239135 BAG16751 AB239136 AB239328 AB558490 BAN82438 AK297899 BAG60219 BC013000 AAH13000 GQ890670 ACX35434 X07384 CAA30297 XM_005268799 XP_005268856 XM_011538189 XP_011536491 XM_011538190 XP_011536492 NM_001160045 NP_001153517 NM_001167609 NP_001161081 NM_005269 NP_005260
Function Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation. {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441}.
Subcellular Location Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1.
Tissue Specificity Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract. {ECO:0000269|PubMed:19878745}.
Top Pathways Hedgehog signaling pathway, Basal cell carcinoma, cAMP signaling pathway

GLI1 - MBS1271307 from MyBioSource

Species Human
Accession BC013000

Human GLI1 cDNA clone(NM_001160045.1) - CDFH007623 from Creative Biomart

Species Human
Accession NM_001160045.1

Human GLI1 cDNA clone(NM_001167609.1) - CDFH007624 from Creative Biomart

Species Human
Accession NM_001167609.1

Human GLI1 ORF Clone(NM_005269.2) - CDCL164735 from Creative Biomart

Species Human
Accession NM_005269.2

Human GLI1 ORF Clone(NM_001160045.1) - CDCR353813 from Creative Biomart

Species Human
Accession NM_001160045.1

Human GLI1 ORF Clone(NM_001160045.1) - CDCR353815 from Creative Biomart

Species Human
Accession NM_001160045.1

Human GLI1 ORF Clone(NM_001167609.1) - CDCR355506 from Creative Biomart

Species Human
Accession NM_001167609.1

Human GLI1 ORF Clone(NM_001167609.1) - CDCR355507 from Creative Biomart

Species Human
Accession NM_001167609.1

Human GLI1 ORF clone (NM_001160045.1) - CDCL111935 from Creative biogene

Species Human

Mouse GLI1 ORF clone (NM_001167609.1) - CDCL111937 from Creative biogene

Species Human

Human GLI1 ORF Clone (BC013000) - CDCS408649 from Creative biogene

Species Human
Accession P08151

Human GLI1 cDNA Clone(NM_001160045.1) - CDFH007623 from Creative biogene

Species Human

Human GLI1 cDNA Clone(NM_001167609.1) - CDFH007624 from Creative biogene

Species Human
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