AQP2

Gene Symbol AQP2
Entrez Gene 359
Alt Symbol AQP-CD, WCH-CD
Species Human
Gene Type protein-coding
Description aquaporin 2 (collecting duct)
Other Description ADH water channel|AQP-2|aquaporin-2|aquaporin-CD|collecting duct water channel protein|water channel protein for renal collecting duct|water-channel aquaporin 2
Swissprots P41181 Q9UD68
Accessions AAD14825 AAD38692 AAK55747 BAA06632 CAA82627 EAW58109 P41181 AI792401 AK055824 AK225940 BC042496 AAH42496 CR542024 CAG46821 S73196 AAB31999 S73197 AAB31998 NM_000486 NP_000477
Function Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Subcellular Location Apical cell membrane {ECO:0000269|PubMed:12194985}; Multi-pass membrane protein {ECO:0000269|PubMed:12194985}. Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:12194985}; Multi- pass membrane protein {ECO:0000269|PubMed:12194985}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12194985}; Multi-pass membrane protein {ECO:0000269|PubMed:12194985}. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
Tissue Specificity Expressed in renal collecting tubules.
Top Pathways Vasopressin-regulated water reabsorption

AQP2 Antibody - 3487 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using AQP2 Antibody.

AQP2 (C-17) - sc-9882 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AQP2 (C-17): sc-9882. Western blot analysis of AQP2 expression in rat kidney tissue extract. Upper band represents glycosylated form.

AQP2 (H-40) - sc-28629 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
AQP2 (H-40): sc-28629. Immunoperoxidase staining of formalin fixed, paraffin-embedded human renal cancer tissue showing perinuclear and cytoplasmic staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

AQP2 (N-20) - sc-9880 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AQP2 (N-20): sc-9880. Western blot analysis of AQP2 expression in rat kidney tissue extract. Upper band represents glycosylated form.

AQP2 (E13-21) - sc-47710 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

AQP5 (D-7) - sc-514022 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AQP5 (D-7): sc-514022. Western blot analysis of AQP5 expression in non-transfected: sc-117752 (A) and human AQP5 transfected: sc-173646 (B) 293T whole cell lysates.

Anti-Aquaporin 2 (phospho S256) antibody - ab111346 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111346 at 1/50 dilution staining Aquaporin 2 in Paraffin-embedded Human Brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-Aquaporin 2 antibody - ab15081 from Abcam

Prices $392.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab15081 staining Aquaporin 2 in rat kidney tissue section by IHC(P). Tissue underwent fixation in formalin, embedded in paraffin, heat mediated antigen retrieval in 10mM EDTA buffer pH 8.0 and blocking in 5% serum for 20 minutes at 20°C. The primary antibody, diluted 1/300 in TBSTween and incubated with sample for 1 hour at 20°C. A HRP conjugated goat polyclonal to rabbit was used undiluted as the secondary.   See Abreview

Anti-Aquaporin 2 antibody - ab15116 from Abcam

Prices $378.00
Sizes 25 µl
Host Rabbit
Clonality Polyclonal

Anti-Aquaporin 2 antibody - ab62628 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62628 staining Aquaporin in Mouse embryonic kidney tissue sections by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100 and blocked with 1% BSA for 1 hour at 20°C. Samples were incubated with primary antibody (1/500 in blocking solution) for 1 hour at 20°C. An Alexa Fluor® 568-conjugated Goat anti-rabbit IgG polyclonal (1/1000) was used as the secondary antibody.See Abreview

Anti-Aquaporin 2 antibody - ab105171 from Abcam

Host Goat
Clonality Polyclonal

Anti-Aquaporin 2 antibody - ab78230 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of acquaporin 2 expression in Formalin-Fixed Paraffin Embedded human kidney using 20 µg/ml ab78230

Anti-Aquaporin 2 antibody - C-terminal - ab85876 from Abcam

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab85876 staining Aquaporin 2 - C-terminal in Rat kidney tissue sections by Immunohistochemistry (IHC-P - paraffin-embedded sections). Tissue was fixed with 10% NBF and blocked with 25% serum free protein block for 5 minutes at 25°C; antigen retrieval was by heat mediation with a Tris/EDTA (pH 9.0) buffer. Samples were incubated with primary antibody (1/5000 in serum free antibody diluent) for 30 minutes. An undiluted HRP-conjugated Goat anti-rabbit IgG polyclonal was used as the secondary antibody.See Abreview

Anti-AQP2 / Aquaporin 2 Antibody (C-Terminus) - LS-C20759 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-AQP2 / Aquaporin 2 Antibody (N-Terminus, Biotin) - LS-C3801 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-AQP2 / Aquaporin 2 Antibody (C-Terminus) - LS-C20760 from LifeSpan Bioscience

Prices $435.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-AQP2 / Aquaporin 2 Antibody (N-Terminus) - LS-C20761 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-AQP2 / Aquaporin 2 Antibody (N-Terminus) - LS-C47035 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AQP2 / Aquaporin 2 Antibody (phospho-Ser261) - LS-C126878 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AQP2 / Aquaporin 2 Antibody (C-Terminus) - LS-C137167 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AQP2 / Aquaporin 2 Antibody (aa222-271) - LS-C117792 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HeLa cells, using Aquaporin 2 (Ab-256) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-AQP2 / Aquaporin 2 Antibody (phospho-Ser261) - LS-C53453 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of rat kidney lysate showing specific immunolabeling of the ~29k and 37k glycosylated form of the AQP2 protein phosphorylated at Ser261. Immunolabeling is blocked by the phospho-peptide used as antigen (peptide) but not by the corresponding.

Anti-AQP2 / Aquaporin 2 Antibody (aa161-210) - LS-C116863 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
AQP2 / Aquaporin-2 antibody LS-C116863 Western blot of Mouse Heart lysate.

Anti-AQP2 / Aquaporin 2 Antibody (aa177-271, Biotin) - LS-C297506 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AQP2 / Aquaporin 2 Antibody (phospho-Ser269) - LS-C150361 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Search more