| Gene Symbol |
Pak1
|
| Entrez Gene |
18479
|
| Alt Symbol |
AW045634, PAK-1, Paka
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
p21 protein (Cdc42/Rac)-activated kinase 1
|
| Other Description |
CDC42/RAC effector kinase PAK-A|activated protein kinase alpha|alpha-PAK|p21-activated kinase 1|p65-PAK|serine/threonine-protein kinase PAK 1
|
| Swissprots |
O88643
|
| Accessions |
CAB41618 EDL16322 EDL16323 EDL16324 EDL16325 EDL16326 O88643 AF082077 AAC32375 AK077497 AK078711 BC055740 BC060157 BC079838 BC145698 BC167167 AAI67167 BY630776 XM_006507434 XP_006507497 XM_006507435 XP_006507498 XM_006507436 XP_006507499 XM_006507437 XP_006507500 XM_011241694 XP_011239996 NM_011035 NP_035165
|
| Function |
Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1,
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin (By similarity). {ECO:0000250}.
|
| Top Pathways |
Axon guidance, ErbB signaling pathway, MAPK signaling pathway, Fc gamma R-mediated phagocytosis, Renal cell carcinoma
|