| Gene Symbol |
Cd40lg
|
| Entrez Gene |
21947
|
| Alt Symbol |
CD154, CD40-L, Cd40l, HIGM1, IGM, IMD3, Ly-62, Ly62, T-BAM, TRAP, Tnfsf5, gp39
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
CD40 ligand
|
| Other Description |
T-cell antigen Gp39|TNF-related activation protein|tumor necrosis factor ligand superfamily member 5
|
| Swissprots |
P27548
|
| Accessions |
AAC13639 AAC13640 CAL44886 CBY45345 EDL42166 P27548 BC119225 AAI19226 EU274582 ABX76043 X65453 CAA46448 NM_011616 NP_035746
|
| Function |
Cytokine that binds to TNFRSF5. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Single-pass type II membrane protein.
|
| Tissue Specificity |
Specifically expressed on activated CD4+ T- lymphocytes.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Primary immunodeficiency, Allograft rejection, Autoimmune thyroid disease, Intestinal immune network for IgA production
|