CENPW

Gene Symbol CENPW
Entrez Gene 387103
Alt Symbol C6orf173, CENP-W, CUG2
Species Human
Gene Type protein-coding
Description centromere protein W
Other Description cancer-up-regulated gene 2 protein|cancer-upregulated gene 2
Swissprots A6NIR0 Q5EE01 A6NJC2
Accessions CAF17861 EAW48119 EAW48120 EAW48121 EAW48122 EAW48123 Q5EE01 AI207187 AL832235 AY902475 AAW82474 BC017928 AAH17928 BC039556 AAH39556 BC046178 AAH46178 BC062798 AAH62798 BM721156 BM874602 NM_001012507 NP_001012525 NM_001286524 NP_001273453 NM_001286525 NP_001273454 NR_104462
Function Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000250, ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:19533040, ECO:0000269|PubMe
Subcellular Location Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus matrix. Nucleus, nucleolus. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis.
Tissue Specificity Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast invasive tumors. Expressed in many cancer cell types. {ECO:0000269|PubMed:17079448, ECO:0000269|PubMed:17610844}.

Human C6ORF173 full length protein - ab166398 from Abcam

Category Protein
Prices $402.00
Sizes 2 µg
Source Wheat germ
Species Human
ab166398 on a 12.5% SDS-PAGE stained with Coomassie Blue.

CENPW / C6orf173 Antibody Blocking Peptide - LS-E19587 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CENPW / C6orf173 Antibody Blocking Peptide - LS-E31301 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

C6ORF173 Blocking Peptide - 33R-1372 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

CENP-W - H00387103-P01 from Acris Antibodies

Category Protein
Species Human

CENP-W (N-term) Control Peptide - AP55507CP-N from Acris Antibodies

Category Peptide
Prices $135.00
Sizes 50 µg

CENPW Peptide - 6943P from ProSci

Category Peptide
Species Human

C6orf173 fusion protein - Ag21580 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human CENPW - CENPW-1046H from Creative Biomart

Category Protein
Source Mammalian Cells
Species Human

Recombinant Human Centromere protein W(CENPW) - CSB-YP701863HU CSB-EP701863HU CSB-BP701863HU CSB-MP701863HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Centromere protein W (CENPW), Recombinant Protein - MBS1299614 from MyBioSource

Category Protein
Prices $820.00, $820.00, $1,045.00, $1,045.00, $1,165.00, $1,165.00, $1,620.00, $1,620.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

CENPW Peptide, Human - M34GP02980H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

CENPW Recombinant Protein Antigen - NBP2-57078PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human
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