Hcn2

Gene Symbol Hcn2
Entrez Gene 15166
Alt Symbol BCNG2, HAC1, trls
Species Mouse
Gene Type protein-coding
Description hyperpolarization-activated, cyclic nucleotide-gated K+ 2
Other Description BCNG-2|HAC-1|brain cyclic nucleotide-gated channel 2|hyperpolarization-activated cation channel 1|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Swissprots O88703 O70506
Accessions AAG43529 EDL31671 O88703 AB154248 BAI44633 AF064873 AAC40125 AJ225122 CAA12406 BC156149 AAI56150 CX242892 NM_008226 NP_032252
Function Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. {ECO:0000269|PubMed:10962006, ECO:0000269|PubMed:11096117, ECO:0000269|PubMed:11741901, ECO:0000269|PubMed:12034718, ECO:0000269|PubMed:12193608, ECO:0000269|PubMed:12968185, ECO:0000269|PubMed:17562314, ECO:0000269|PubMed:23103389}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:10962006, ECO:0000269|PubMed:11096117, ECO:0000269|PubMed:12034718, ECO:0000269|PubMed:12193608, ECO:0000269|PubMed:17562314, ECO:0000269|PubMed:23103389}; Multi-pass membrane protein {ECO:0000269|PubMed:10962006, ECO:0000269|PubMed:11096117, ECO:0000269|PubMed:12034718, ECO:0000269|PubMed:12193608, ECO:0000269|PubMed:17562314, ECO:0000269|PubMed:23103389}.
Tissue Specificity Highly expressed in brain. Detected at low levels in heart, in ventricle, atrium and in sinoatrial node (SAN). {ECO:0000269|PubMed:9630217}.
Top Pathways cAMP signaling pathway

HCN2 CRISPR/Cas9 KO Plasmid (m) - sc-420813 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HCN2 HDR Plasmid (m) - sc-420813-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HCN2 Double Nickase Plasmid (m) - sc-420813-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HCN2 Double Nickase Plasmid (m2) - sc-420813-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HCN2 CRISPR Activation Plasmid (m) - sc-420813-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HCN2 CRISPR Activation Plasmid (m2) - sc-420813-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HCN2 Lentiviral Activation Particles (m) - sc-420813-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HCN2 Lentiviral Activation Particles (m2) - sc-420813-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HCN2 siRNA (m) - sc-145908 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

HCN2 shRNA Plasmid (m) - sc-145908-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

HCN2 shRNA (m) Lentiviral Particles - sc-145908-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU075021 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN33124 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33124 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

HCN2 siRNA (Mouse) - CRM1791 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

HCN2 - MBS8212629 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse HCN2 (NM_008226.2) - SHH310837 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Hcn2(NM_008226.2) - SHH115697 from Creative biogene

Category siRNA
Species Reactivities Mouse

HCN2 CRISPR/Cas9 KO Plasmid (m2) - sc-420813-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HCN2 HDR Plasmid (m2) - sc-420813-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HCN2 shRNA Plasmid (Mouse) - CHM1791 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

HCN2 miRNA 3'UTR clone - MiUTR1M-05556 from Creative biogene

Species Reactivities Mouse
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