| Gene Symbol | Espn |
|---|---|
| Entrez Gene | 56226 |
| Alt Symbol | je |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | espin |
| Other Description | actin cytoskeletal regulatory protein|ectoplasmic specialization protein|jerker |
| Swissprots | Q9QY27 Q80ZC2 B1AWP3 Q80ZC3 A2AK06 A2AK13 A2AK09 Q80ZC0 Q6GYS0 B1AWP6 Q80ZC1 B1AWQ2 Q6GYS1 Q9ET47 |
| Accessions | AAF18322 AAF18323 EDL14926 EDL14927 Q9ET47 AF134857 AAD24481 AF239886 AAF98134 AF540942 AAO50326 AF540943 AAO50327 AF540944 AAO50328 AF540945 AAO50329 AK002284 BAB21987 AK145160 BAE26267 AK146701 AK165010 AK181113 AY587570 AAT46472 AY587571 AAT46473 BC044723 AAH44723 BC057888 AAH57888 BY739473 CJ194793 CJ319194 XM_006539059 XP_006539122 XM_006539060 XP_006539123 XM_006539061 XP_006539124 XM_006539063 XP_006539126 NM_019585 NP_062531 NM_207687 NP_997570 NM_207688 NP_997571 NM_207689 NP_997572 NM_207690 NP_997573 NM_207691 NP_997574 |
| Function | Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells. {ECO:0000269|PubMed:14657236, ECO:0000269|PubMed:15190118}. |
| Subcellular Location | Isoform 5: Cytoplasm, cytoskeleton. Cell projection, dendritic spine. |
| Tissue Specificity | Expressed at high concentration in the microvillar parallel actin bundle (PAB) of hair cells stereocilia in the cochlea and vestibular system. Detected also at high levels of a number of other sensory cell types, including taste receptor cells, solitary chemoreceptor cells, vomeronasal sensory neurons and Merkel cells. Isoforms 2, 3, 4 and 5 are expressed in Purkinje cells dentritic spines. {ECO:0000269|PubMed:10975527, ECO:0000269|PubMed:12598619, ECO:0000269|PubMed:15190118}. |
Espin CRISPR/Cas9 KO Plasmid (m) - sc-425049 from Santa Cruz Biotechnology
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Espin HDR Plasmid (m) - sc-425049-HDR from Santa Cruz Biotechnology
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Espin Double Nickase Plasmid (m) - sc-425049-NIC from Santa Cruz Biotechnology
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Espin Double Nickase Plasmid (m2) - sc-425049-NIC-2 from Santa Cruz Biotechnology
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Espin CRISPR Activation Plasmid (m) - sc-425049-ACT from Santa Cruz Biotechnology
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Espin CRISPR Activation Plasmid (m2) - sc-425049-ACT-2 from Santa Cruz Biotechnology
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Espin Lentiviral Activation Particles (m) - sc-425049-LAC from Santa Cruz Biotechnology
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Espin Lentiviral Activation Particles (m2) - sc-425049-LAC-2 from Santa Cruz Biotechnology
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Espin siRNA (m) - sc-40510 from Santa Cruz Biotechnology
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Espin shRNA Plasmid (m) - sc-40510-SH from Santa Cruz Biotechnology
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Espin shRNA (m) Lentiviral Particles - sc-40510-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU059911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN30785 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30785 from Sigma-Aldrich
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ESPN siRNA (Mouse) - CRM5687 from Cohesion Biosciences
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ESPN - MBS8235394 from MyBioSource
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shRNA set against Mouse Espn (NM_019585.3) - SHH287377 from Creative biogene
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shRNA set against Mouse Espn(NM_019585.3) - SHG210673 from Creative biogene
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shRNA set against Mouse Espn(NM_207687.2) - SHG210727 from Creative biogene
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shRNA set against Mouse Espn(NM_207690.2) - SHG210745 from Creative biogene
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shRNA set against Mouse Espn(NM_207688.2) - SHG210763 from Creative biogene
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shRNA set against Mouse Espn(NM_207691.2) - SHH039395 from Creative biogene
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shRNA set against Mouse Espn(NM_207689.2) - SHH039431 from Creative biogene
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ESPN shRNA Plasmid (Mouse) - CHM5687 from Cohesion Biosciences
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ESPN miRNA 3'UTR clone - MiUTR1M-04481 from Creative biogene
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