Eno1
| Gene Symbol | Eno1 |
|---|---|
| Entrez Gene | 24333 |
| Alt Symbol | Nne |
| Species | Rat |
| Gene Type | protein-coding |
| Description | enolase 1, (alpha) |
| Other Description | 2-phospho-D-glycerate hydro-lyase|alpha enolase|alpha-enolase|enolase 1, alpha non-neuron|non-neural enolase |
| Swissprots | Q66HI3 P04764 Q6AYV3 Q6P504 |
| Accessions | EDL81184 P04764 AF241613 AAK01319 BC063174 AAH63174 BC078896 AAH78896 BC081847 AAH81847 BC090069 AAH90069 BC091572 AAH91572 BC097343 AAH97343 CB809779 FQ214707 FQ225935 X02610 CAA26456 XM_006239444 XP_006239506 NM_001109908 NP_001103378 NM_012554 NP_036686 |
| Function | Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. |
| Subcellular Location | Cytoplasm. Cell membrane. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. |
| Tissue Specificity | Expressed in flagella of epididymal sperm. The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. {ECO:0000269|PubMed:19423663}. |
| Top Pathways | Glycolysis / Gluconeogenesis, RNA degradation, Biosynthesis of amino acids, Carbon metabolism |
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