E2F1

Gene Symbol E2F1
Entrez Gene 1869
Alt Symbol E2F-1, RBAP1, RBBP3, RBP3
Species Human
Gene Type protein-coding
Description E2F transcription factor 1
Other Description PBR3|PRB-binding protein E2F-1|RBAP-1|RBBP-3|retinoblastoma-associated protein 1|retinoblastoma-binding protein 3|transcription factor E2F1
Swissprots Q13143 Q92768 Q01094
Accessions AAC50719 AAD14150 AAM47604 CAM91159 CAN37617 CAY56011 CBX53852 EAW76299 EAW76300 Q01094 AF086380 BC005098 AAH05098 BC050369 AAH50369 BC058902 AAH58902 M96577 AAA35782 S49592 AAB24289 NM_005225 NP_005216
Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000250|UniProtKB:Q61501, ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:8170954}.
Subcellular Location Nucleus.
Top Pathways MicroRNAs in cancer, Cell cycle, HTLV-I infection, Prostate cancer, Glioma

Human E2F1 cDNA clone(NM_005225.2) - CDFH005578 from Creative Biomart

Species Human
Accession NM_005225.2

Human E2F1 ORF clone (NM_005225.2) - CDCR058154 from Creative biogene

Species Human

Human E2F1 cDNA Clone(NM_005225.2) - CDFH005578 from Creative biogene

Species Human
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