| Gene Symbol |
Map3k11
|
| Entrez Gene |
309168
|
| Alt Symbol |
Mlk-3, Mlk3, RHOE
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase kinase 11
|
| Other Description |
mixed lineage kinase 3
|
| Swissprots |
Q80YF1 Q66HA1
|
| Accessions |
EDM12519 Q66HA1 AY240868 AAO91627 BC081952 AAH81952 NM_001013150 NP_001013168
|
| Function |
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Location is cell cycle dependent. {ECO:0000250}.
|
| Top Pathways |
MAPK signaling pathway, Non-alcoholic fatty liver disease (NAFLD)
|