Ace

Gene Symbol Ace
Entrez Gene 11421
Alt Symbol AW208573, CD143
Species Mouse
Gene Type protein-coding
Description angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Other Description angiotensin-converting enzyme|dipeptidyl carboxypeptidase I|dipeptidyl peptidase|kininase II
Swissprots P09470 Q6GTS2 P22967
Accessions AAA37151 AAP03650 EDL34253 EDL34254 EDL34255 P09470 AK087056 BAC39791 AK154632 BAE32728 AK161020 BAE36151 AK164780 BC034367 AAH34367 BC040404 AAH40404 BC052531 AAH52531 BC083109 AAH83109 BC110362 AAI10363 BY197083 BY210311 J03940 AAA37146 J04946 AAA37147 J04947 AAA37148 M55333 AAA37149 NM_001281819 NP_001268748 NM_009598 NP_033728 NM_207624 NP_997507
Function Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm. {ECO:0000269|PubMed:15665832, ECO:0000269|PubMed:7753170, ECO:0000269|PubMed:8642790}.
Subcellular Location Angiotensin-converting enzyme, soluble form: Secreted {ECO:0000250}.
Tissue Specificity Testis-specific isoform is expressed in spermatocytes, adult testis.
Top Pathways Hypertrophic cardiomyopathy (HCM), Chagas disease (American trypanosomiasis), Renin-angiotensin system

Mouse ACE ORF clone(NM_207624.5) - CDCH014727 from Creative Biomart

Species Mouse
Accession NM_207624.5

Mouse ACE ORF clone(NM_009598.2) - CDCH014728 from Creative Biomart

Species Mouse
Accession NM_009598.2

Mouse Ace ORF Clone(NM_207624.5) - CDCL152911 from Creative Biomart

Species Mouse
Accession NM_207624.5

Mouse Ace ORF Clone(NM_009598.2) - CDCR247531 from Creative Biomart

Species Mouse
Accession NM_009598.2

Mouse Ace ORF Clone(NM_009598.2) - CDCR247532 from Creative Biomart

Species Mouse
Accession NM_009598.2

Mouse ACE ORF clone(NM_207624.5) - CDCH014727 from Creative biogene

Species Mouse

Mouse Ace ORF Clone(NM_009598.2) - CDCR247531 from Creative biogene

Species Mouse
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