UBE2D1

Gene Symbol UBE2D1
Entrez Gene 7321
Alt Symbol E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A
Species Human
Gene Type protein-coding
Description ubiquitin-conjugating enzyme E2D 1
Other Description UBC4/5 homolog|stimulator of Fe transport|ubiquitin carrier protein D1|ubiquitin-conjugating enzyme E2 D1|ubiquitin-conjugating enzyme E2(17)KB 1|ubiquitin-conjugating enzyme E2-17 kDa 1|ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)|ubiquitin-protein ligase D1
Swissprots A8K786 P51668 A6NLF6
Accessions CAC82097 EAW54167 EAW54168 EAW54169 EAW54170 P51668 AF020761 AF257220 AAM81086 AI566662 AJ272367 CAC82177 AK291901 BAF84590 BC005980 AAH05980 BC015997 AAH15997 BI598342 BM468116 BM970335 BT007041 AAP35690 DA618122 DA677507 DQ893111 ABM84037 DQ896385 ABM87384 X78140 CAA55019 NM_001204880 NP_001191809 NM_003338 NP_003329
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4. {ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:18845142}.
Tissue Specificity Ubiquitous. Up-regulated in livers of iron- overloaded patients with hereditary hemochromatosis. {ECO:0000269|PubMed:12480712, ECO:0000269|PubMed:9362508}.
Top Pathways Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

UBE2D1 CRISPR/Cas9 KO Plasmid (h) - sc-417341 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE2D1 HDR Plasmid (h) - sc-417341-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE2D1 Double Nickase Plasmid (h) - sc-417341-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE2D1 Double Nickase Plasmid (h2) - sc-417341-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE2D1 CRISPR Activation Plasmid (h) - sc-417341-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE2D1 CRISPR Activation Plasmid (h2) - sc-417341-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE2D1 Lentiviral Activation Particles (h) - sc-417341-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE2D1 Lentiviral Activation Particles (h2) - sc-417341-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UBE2D1 siRNA (h) - sc-41679 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UBE2D1 shRNA Plasmid (h) - sc-41679-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UBE2D1 shRNA (h) Lentiviral Particles - sc-41679-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU052051 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22356 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22356 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10758 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10758

UBE2D1 siRNA (Human) - CRH5004 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UbcH5a/UBE2D1 RNAi - H00007321-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

UBE2D1 - MBS8220728 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human UBE2D1 (NM_003338.4) - SHH438880 from Creative biogene

Category siRNA
Species Reactivities Human

Human UBE2D1 siRNA - orb265506 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UBE2D1 shRNA Plasmid (Human) - CHH5004 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UBE2D1 miRNA 3'UTR clone - MiUTR4H-TG09577 from Creative biogene

Species Reactivities Human
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