| Gene Symbol |
TMOD1
|
| Entrez Gene |
7111
|
| Alt Symbol |
D9S57E, ETMOD, TMOD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tropomodulin 1
|
| Other Description |
E-Tmod|e-tropomodulin|erythrocyte tropomodulin|tropomodulin-1
|
| Swissprots |
B2RB77 P28289 Q9BUF1 Q5T7W3
|
| Accessions |
AAG30124 EAW58845 EAW58846 P28289 AF131836 AK095748 BAG53119 AK096156 AK314533 BAG37124 BC002660 AAH02660 BU783086 DA015088 DQ893027 ABM83953 DQ896271 ABM87270 M77016 AAA61224 NM_001166116 NP_001159588 NM_003275 NP_003266
|
| Function |
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. {ECO:0000269|PubMed:8002995}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574). {ECO:0000269|PubMed:25250574}.
|
| Tissue Specificity |
Highly expressed in the erythrocyte, heart and skeletal muscle.
|
![Western Blot: Tropomodulin 1 Overexpression Lysate (Adult Normal) [NBL1-17115] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Tropomodulin 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7282_Tropomodulin%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17115-img0002.jpg)