FMO3

Gene Symbol FMO3
Entrez Gene 2328
Alt Symbol FMOII, TMAU, dJ127D3.1
Species Human
Gene Type protein-coding
Description flavin containing monooxygenase 3
Other Description FMO 3|FMO II|FMO form 2|dimethylaniline monooxygenase [N-oxide-forming] 3|dimethylaniline oxidase 3|hepatic flavin-containing monooxygenase 3|hepatic flavin-containing monooxygenase-3|trimethylamine monooxygenase
Swissprots Q8N5N5 Q14854 P31513 B2R816
Accessions AAC51932 AAW65372 EAW90886 EAW90887 EAW90888 P31513 AI478384 AK223166 BAD96886 AK296105 BAH12258 AK298406 BAH12779 AK310785 AK313197 BAG36013 BC032016 AAH32016 BM453951 DQ892429 ABM83355 DQ895643 ABM86569 M83772 AAA86284 Z47552 CAA87632 XM_005245044 XP_005245101 XM_011509345 XP_011507647 XM_011509346 XP_011507648 NM_001002294 NP_001002294 NM_006894 NP_008825
Function Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds.
Subcellular Location Microsome membrane. Endoplasmic reticulum membrane.
Tissue Specificity Liver.
Top Pathways Drug metabolism - cytochrome P450

FMO3 (M-40) - sc-367514 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FMO3 (M-40): sc-367514. Western blot analysis of FMO3 expression in Jurkat whole cell lysate.

FMO3 (T-17) - sc-51288 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FMO3 (T-17): sc-51288. Western blot analysis of FMO3 expression in rat liver tissue extract.

FMO3 (H-40) - sc-367513 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-FMO3 antibody - ab154089 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-FMO3 antibody (ab154089) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

Anti-FMO3 antibody - ab154083 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-FMO3 antibody (ab154083) at 1/500 dilution + H1299 whole cell lysate at 30 µg

Anti-FMO3 antibody - ab92902 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-FMO3 antibody (ab92902) at 1/500 dilution + Human liver tissue lysate at 50 µg

Anti-FMO3 antibody [EPR6967] - ab126790 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6967
Overlay histogram showing HepG2 cells stained with ab126790 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab126790, 1/65 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-FMO3 antibody [EPR6968] - ab126711 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6968
All lanes : Anti-FMO3 antibody [EPR6968] (ab126711) at 1/1000 dilution (unpurified)Lane 1 : Human fetal liver tissue lysateLane 2 : Human fetal kidney tissue lysateLysates/proteins at 10 µg per lane.SecondaryHRP-conjugated goat anti-rabbit IgG at 1/2000 dilution

Anti-FMO3 Antibody (N-Terminus, AP) - LS-C225501 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FMO3 Antibody (N-Terminus, APC) - LS-C225502 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FMO3 Antibody (N-Terminus, Biotin) - LS-C225504 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FMO3 Antibody (Internal, clone EPR6967) - LS-C152398 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6967
Western blot analysis on (A) rat kidney, (B) mouse liver, (C) rat liver, and (D) fetal liver lysates using anti-FMO3 antibody.

Anti-FMO3 Antibody (N-Terminus, FITC) - LS-C225505 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FMO3 Antibody (aa300-349) - LS-C145266 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FMO3 antibody LS-C145266 Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.

Anti-FMO3 Antibody (N-Terminus, Azide-free, HRP) - LS-C225506 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FMO3 Antibody (N-Terminus, PE) - LS-C225507 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FMO3 Antibody - LS-C307583 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-FMO3 Antibody (N-Terminus) - LS-C116265 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FMO3 antibody LS-C116265 Western blot of OVCAR-3 cell lysate.

Anti-FMO3 Antibody - LS-C310380 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FMO3 Antibody - LS-C341370 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FMO3 Antibody (N-Terminus, Azide-free) - LS-C327405 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FMO3 Antibody (Internal, clone EPR6968) - LS-C152333 from LifeSpan Bioscience

Prices $480.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6968
IHC of paraffin-embedded human liver tissue using anti-FMO3 antibody.

Anti-FMO3 Antibody (aa1-291, clone 3H1) - LS-C340468 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H1
IHC of paraffin-embedded Carcinoma of Human liver tissue using anti-FMO3 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0)(1:150).

Anti-FMO3 Antibody - LS-C331753 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of mouse liver cell lines, using FMO3 antibody.

Anti-FMO3 Antibody (aa76-90) - LS-C312911 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of FMO3 antibody. All lanes: Anti-FMO3 at 0.5ug/ml. Lane 1: Rat Liver Tissue Lysate at 40ug. Lane 2: Rat Liver Tissue Lysate at 40ug. Predicted bind size: 60KD. Observed bind size: 60KD.
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