| Gene Symbol | FMO3 |
|---|---|
| Entrez Gene | 2328 |
| Alt Symbol | FMOII, TMAU, dJ127D3.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | flavin containing monooxygenase 3 |
| Other Description | FMO 3|FMO II|FMO form 2|dimethylaniline monooxygenase [N-oxide-forming] 3|dimethylaniline oxidase 3|hepatic flavin-containing monooxygenase 3|hepatic flavin-containing monooxygenase-3|trimethylamine monooxygenase |
| Swissprots | Q8N5N5 Q14854 P31513 B2R816 |
| Accessions | AAC51932 AAW65372 EAW90886 EAW90887 EAW90888 P31513 AI478384 AK223166 BAD96886 AK296105 BAH12258 AK298406 BAH12779 AK310785 AK313197 BAG36013 BC032016 AAH32016 BM453951 DQ892429 ABM83355 DQ895643 ABM86569 M83772 AAA86284 Z47552 CAA87632 XM_005245044 XP_005245101 XM_011509345 XP_011507647 XM_011509346 XP_011507648 NM_001002294 NP_001002294 NM_006894 NP_008825 |
| Function | Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds. |
| Subcellular Location | Microsome membrane. Endoplasmic reticulum membrane. |
| Tissue Specificity | Liver. |
| Top Pathways | Drug metabolism - cytochrome P450 |