STUB1

Gene Symbol	STUB1
Entrez Gene	10273
Alt Symbol	CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1
Species	Human
Gene Type	protein-coding
Description	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Other Description	CLL-associated antigen KW-8|E3 ubiquitin-protein ligase CHIP|antigen NY-CO-7|carboxy terminus of Hsp70-interacting protein|heat shock protein A binding protein 2 (c-terminal)|serologically defined colon cancer antigen 7
Swissprots	O60526 Q969U2 A2IDB9 Q9HBT1 Q9UNE7
Accessions	AAK61242 CAV30716 EAW85756 EAW85757 EAW85758 Q9UNE7 AF039689 AAC18038 AF129085 AAD33400 AF217968 AAG17211 AF432221 AAL99927 BC007545 AAH07545 BC017178 AAH17178 BC022788 AAH22788 BC063617 AAH63617 CB145452 DQ893185 ABM84111 DQ896502 ABM87501 NM_001293197 NP_001280126 NM_005861 NP_005852
Function	E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Negatively regu
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:23973223}. Nucleus {ECO:0000269|PubMed:23973223}. Note=Translocates to the nucleus in response to inflammatory signals in regulatory T-cells (Treg). {ECO:0000269|PubMed:23973223}.
Tissue Specificity	Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung. {ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11435423}.
Top Pathways	Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human STUB1 full length protein - ab188737 from Abcam Category Protein Prices $572.00 Sizes 50 µg Source E. coli Species Human

Human STUB1 full length protein - ab139765 from Abcam Category Protein Source E. coli Species Human

Human STUB1 full length protein - ab82791 from Abcam Category Protein Source E. coli Species Human

Human STUB1 full length protein - ab61295 from Abcam Category Protein Source E. coli Species Human

Human STUB1 peptide - ab39645 from Abcam Category Peptide

Human STUB1 peptide - ab4934 from Abcam Category Peptide Species Human

Human STUB1 peptide - ab45460 from Abcam Category Peptide Species Human

STUB1 / CHIP Antibody Blocking Peptide - LS-E1469 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STUB1 / CHIP Antibody Blocking Peptide - LS-E25309 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STUB1 / CHIP Antibody Blocking Peptide - LS-E8235 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STUB1 / CHIP Antibody Blocking Peptide - LS-E15847 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STUB1 / CHIP Antibody Blocking Peptide - LS-E15848 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHIP/STUB1 Recombinant Protein - H00010273-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CHIP/STUB1 Partial Recombinant Protein - H00010273-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CHIP/STUB1 Protein - NBC1-18849 from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µg Species Human

Recombinant Human CHIP/STUB1 Protein - NBP1-99579 from Novus Biologicals Category Protein Prices $275.00 Sizes 25 µg Source E. coli Species Human

CHIP/STUB1 Peptide - P2063 from Novus Biologicals Category Peptide Species Human

CHIP/STUB1 Peptide - P2062 from Novus Biologicals Category Peptide Species Human

STUB1-Antibody-C-term-Blocking-peptide - BP12177b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

STUB1-Antibody-C-term-Blocking-peptide - BP6413b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

STUB1-Antibody-N-term-Blocking-peptide - BP6413a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

STUB1 recombinant protein - GTX65315 from GeneTex Category Protein Prices $319.00 Sizes 25 μg Source E. coli Species Human

STUB1 blocking peptide - GTX89724-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Recombinant Human CHIP/STUB1, CF - E3-220-050 from R&D Systems Category Protein Source E. coli-derived,

STUB1 Protein (OPPA02087) - OPPA02087 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Search more