SRSF2

Gene Symbol SRSF2
Entrez Gene 6427
Alt Symbol PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b
Species Human
Gene Type protein-coding
Description serine/arginine-rich splicing factor 2
Other Description SR splicing factor 2|splicing component, 35 kDa|splicing factor SC35|splicing factor, arginine/serine-rich 2
Swissprots B4DN89 H0YG49 B3KWD5 Q01130
Accessions AAA60162 CAA53383 CAH25911 EAW89439 EAW89440 EAW89441 EAW89442 EAW89443 EAW89444 EAW89445 EAW89446 EAW89447 EAW89448 Q01130 AK092489 BAC03903 AK093626 BAC04206 AK097069 BAG53419 AK098209 BAG53593 AK123712 BAG53944 AK124792 BAG54097 AK126432 BAG54327 AK223252 BAD96972 AK297813 BAG60151 BC000339 AAH00339 BC001303 AAH01303 BC063570 BC066958 AAH66958 BC070086 AAH70086 BT007250 AAP35914 DA513281 DC361254 DQ891210 ABM82136 DQ894393 ABM85319 EB388696 M90104 AAA60306 X62447 CAA44307 XR_429913 XR_429914 XR_934515 XR_934516 NM_001195427 NP_001182356 NM_003016 NP_003007 NR_036608
Function Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}.
Subcellular Location Nucleus {ECO:0000269|PubMed:21157427}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21157427}. Nucleus speckle {ECO:0000269|PubMed:21157427}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear specke to nucleoplasm.
Top Pathways Spliceosome, Herpes simplex infection

SFRS2-Over-expression-Lysate - LY11812a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag PRPH (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PRPH gene

SFRS2 293T Cell Transient Overexpression Lysate(Denatured) - H00006427-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

SC35 Overexpression Lysate (Denatured) - H00006427-T01 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl
Species Human
Lane 1: SFRS2 transfected lysate (19.8 KDa). Lane 2: Non-transfected lysate.

Panoply™ Human SRSF2 Knockdown Stable Cell Line - CSC-DC015180 from Creative biogene

Category Cell Line
Species Human
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