CDC4

Gene Symbol CDC4
Entrez Gene 850539
Alt Symbol -
Species Yeast
Gene Type protein-coding
Description SCF ubiquitin ligase complex subunit CDC4
Other Description -
Swissprots D6VTM1 P07834
Accessions DAA12431 P07834 NM_001179957 NP_116585
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. Directs ubiquitination of the phosphorylated CDK inhibitor SIC1. Involved in the degradation of CDC6 together with CDC34/UBC3 and CDC53, and in restricting the degradation of FAR1 to the nucleus. Is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. Required for HTA1-HTB1 locus transcription activation. Required for G1/S and G2/M transition. {ECO:0000269|PubMed:10213692, ECO:0000269|PubMed:10409741, ECO:0000269|PubMed:11080155, ECO:0000269|PubMed:7813440, ECO:0000269|PubMed:9312022, ECO:0000269|PubMed:9312054, ECO:0000269|PubMed:9346238, ECO:00
Subcellular Location Nucleus {ECO:0000269|PubMed:11080155}.
Top Pathways Cell cycle - yeast, Ubiquitin mediated proteolysis

Cdc4 (yN-19) - sc-6714 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cdc4 (yN-19): sc-6714. Western blot analysis of Cdc4 expression in S. cerevisiae whole cell lysate.

Cdc4 (yC-20) - sc-6715 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cdc4 (yC-20): sc-6715. Western blot analysis of Cdc4 expression in S. cerevisiae whole cell lysate.
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