MEFV

Gene Symbol	MEFV
Entrez Gene	4210
Alt Symbol	FMF, MEF, TRIM20
Species	Human
Gene Type	protein-coding
Description	Mediterranean fever
Other Description	marenostrin|pyrin
Swissprots	D3DUC0 Q96PN5 Q3MJ84 F5H0Q3 O15553 Q96PN4
Accessions	AAD26152 AAK97223 AAK97224 ABQ57362 BAM20997 CAA05906 EAW85382 EAW85383 O15553 AF018080 AAB70557 AK298660 BAG60828 BC101511 AAI01512 BC101537 AAI01538 FJ785717 ACV82585 FJ785718 ACV82586 FJ785719 ACV82587 FJ785720 ACV82588 FJ785721 ACV82589 FJ785722 ACV82590 Y14441 CAA74793 NM_000243 NP_000234 NM_001198536 NP_001185465
Function	Involved in innate immunity and the inflammatory response. Interacts with several components of the inflammasome complex, a large oligomeric structure which recruits and activates CASP1 and ultimately induces maturation of cytokines such as IL1B. However, the exact role of MEFV in the inflammatory pathway is uncertain as contradictory effects on IL1B processing have been reported in different experimental systems. Has been shown to activate IL1B production (PubMed:16037825). Has also been shown to inhibit IL1B production (PubMed:16785446, PubMed:17431422). Also required for PSTPIP1-induced PYCARD oligomerization and for formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Can reduce PYCARD-induced apoptosis. Recruits PSTPIP1 to pyroptosomes, and required for PSTPIP1 oligomerization. {ECO:0000269|PubMed:10807793, ECO:0000269|PubMed:11468188, ECO:0000269|PubMed:16037825, ECO:0000269|PubMed:16785446,
Subcellular Location	Isoform 1: Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection, lamellipodium. Nucleus. Note=Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles. In pre- apoptotic cells, colocalizes with PYCARD/ASC in large specks (pyroptosomes). In migrating monocytes, strongly polarized at the leading edge of the cell where it colocalizes with polymerizing actin and PYCARD/ASC.
Tissue Specificity	Expressed in peripheral blood leukocytes, particularly in mature granulocytes and to a lesser extent in monocytes but not in lymphocytes. Detected in spleen, lung and muscle, probably as a result of leukocyte infiltration in these tissues. Not expressed in thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, liver, kidney, pancreas. Expression detected in several myeloid leukemic, colon cancer, and prostate cancer cell lines. {ECO:0000269|PubMed:10666224, ECO:0000269|PubMed:10807793, ECO:0000269|PubMed:11115844}.
Top Pathways	NOD-like receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Pyrin / MEFV / MEF ELISA Kit (Sandwich ELISA) - LS-F12024 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Pyrin (MEFV), Human, ELISA Kit - CSB-EL013675HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Pyrin, MEFV, Human, ELISA Kit - E2100h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Mediterranean fever, ELISA Kit - MBS942209 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 6.25 pg/ml. Range 25 pg/ml -1600 pg/ml.

Human Pyrin(MEFV) ELISA kit - CSB-EL013675HU from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Rat Pyrin / MEFV / MEF ELISA Kit (Custom ELISA) - LS-F19242 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse Pyrin / MEFV / MEF ELISA Kit (Custom ELISA) - LS-F19243 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human Pyrin ELISA Kit - abx251434 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human Pyrin (MEFV) ELISA Kit - EKC35323 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

Human Pyrin ELISA Kit - EKE54111 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.078 ng/mL Range 0.156-10 ng/mL

MEFV - EKH4204 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

MEFV ELISA Kit (Human) : 96 Wells (OKEH01493) - OKEH01493 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.078 ng/mL Range 0.156 - 10 ng/mL

Human MEFV ELISA Kit - E023947 from Biobool Category ELISA Kit Sensitivity 6.25 pg/ml.

Human Pyrin ELISA Kit - EK4284 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.15ng/mL Range 0.312-20 ng/mL

anti-MEFV antibody - ARG63829 from Arigo Biolaboratories Category ELISA Kit

Pyrin (MEFV), ELISA Kit - MBS9370410 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyrin (MEFV), ELISA Kit - MBS9374365 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyrin (MEFV), ELISA Kit - MBS9381229 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyrin (MEFV), ELISA Kit - MBS9375068 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyrin (MEFV), ELISA Kit - MBS9371116 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyrin (MEFV), ELISA Kit - MBS9372359 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyrin, ELISA Kit - MBS9428110 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 0.078ng/mL Range 0.156-10 ng/mL

Pyrin, ELISA Kit - MBS289695 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

Pyrin, ELISA Kit - MBS760519 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Pyrin (MEFV), ELISA Kit - MBS9377991 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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