| Gene Symbol | SMC4 |
|---|---|
| Entrez Gene | 850775 |
| Alt Symbol | - |
| Species | Yeast |
| Gene Type | protein-coding |
| Description | condensin subunit SMC4 |
| Other Description | - |
| Swissprots | Q12267 D6VY86 |
| Accessions | DAA09402 Q12267 NM_001181973 NP_013187 |
| Function | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. |
| Subcellular Location | Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. |
| Top Pathways | Cell cycle - yeast |