| Gene Symbol |
CLK1
|
| Entrez Gene |
1195
|
| Alt Symbol |
CLK, CLK/STY, STY
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CDC-like kinase 1
|
| Other Description |
CDC28/CDC2-like kinase|dual specificity protein kinase CLK1|protein tyrosine kinase STY
|
| Swissprots |
Q0P694 Q8N5V8 B4DFW7 P49759
|
| Accessions |
AAY14722 CAV30732 EAW70215 EAW70216 EAW70217 EAW70218 EAW70219 P49759 AI251890 AK025306 AK289365 BAF82054 AK294295 BAG57578 AK307301 AK316127 BAH14498 BC028149 AAH28149 BC028573 BC031549 AAH31549 BE241788 DA225472 DB164846 L29219 AAA61480 L29222 AAB59459 M59287 NM_001162407 NP_001155879 NM_004071 NP_004062 NR_027855 NR_027856 NM_001024646
|
| Function |
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Endothelial cells. {ECO:0000269|PubMed:19168442}.
|
| Top Pathways |
Legionellosis
|
![Western Blot: CLK1 Overexpression Lysate (Adult Normal) [NBL1-09273] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CLK1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3545_CLK1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09273-img0002.jpg)