| Gene Symbol |
GABRB1
|
| Entrez Gene |
2560
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
gamma-aminobutyric acid (GABA) A receptor, beta 1
|
| Other Description |
GABA(A) receptor subunit beta-1|GABA(A) receptor, beta 1|gamma-aminobutyric acid A receptor beta 1|gamma-aminobutyric acid receptor subunit beta-1
|
| Swissprots |
Q16166 Q8TBK3 D6REL3 B2R6U7 P18505
|
| Accessions |
AAA35862 AAF88061 EAW93030 EAW93031 EAW93032 P18505 AK094991 AK225167 AK225686 AK293691 BAG57128 AK296023 BAG58792 AK307120 AK312720 BAG35594 BC022449 AAH22449 DC352362 DQ892357 ABM83283 DQ893370 ABM84296 DQ895564 ABM86490 DQ896690 ABM87689 DQ896691 ABM87690 KJ534841 AHW56481 KJ535054 AHW56693 S70733 AAB30712 X14767 CAA32875 XM_011513678 XP_011511980 NM_000812 NP_000803
|
| Function |
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
|
| Top Pathways |
GABAergic synapse, Morphine addiction, Nicotine addiction, Retrograde endocannabinoid signaling, Neuroactive ligand-receptor interaction
|
![Western Blot: GABA A Receptor beta 1 Overexpression Lysate (Adult Normal) [NBL1-10920] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GABA A Receptor beta 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9438_GABA%2520A%2520Receptor%2520beta%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10920-img0002.jpg)