| Gene Symbol | HCFC1 |
|---|---|
| Entrez Gene | 3054 |
| Alt Symbol | CFF, HCF, HCF-1, HCF1, HFC1, MRX3, PPP1R89, VCAF |
| Species | Human |
| Gene Type | protein-coding |
| Description | host cell factor C1 |
| Other Description | VP16-accessory protein|host cell factor 1|protein phosphatase 1, regulatory subunit 89 |
| Swissprots | Q6P4G5 P51610 |
| Accessions | AAB27583 CAA55790 EAW72767 EAW72768 EAW72769 P51610 BC010606 BC019887 AAH19887 BC030560 AAH30560 BC063435 AAH63435 DQ655939 GU014839 ACX32326 L20010 XM_006724815 XP_006724878 XM_006724816 XP_006724879 XM_011531144 XP_011529446 XM_011531145 XP_011529447 XM_011531146 XP_011529448 XM_011531147 XP_011529449 XM_011531148 XP_011529450 XM_011531149 XP_011529451 XM_011531150 XP_011529452 NM_005334 NP_005325 |
| Function | Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|Pub |
| Subcellular Location | Cytoplasm. Nucleus. Note=HCFC1R1 modulates its subcellular localization and overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. Nuclear in general, but uniquely cytoplasmic in trigeminal ganglia, becoming nuclear upon HSV reactivation from the latent state. Non-processed HCFC1 associates with chromatin. Colocalizes with CREB3 and CANX in the ER. |
| Tissue Specificity | Highly expressed in fetal tissues and the adult kidney. Present in all tissues tested. {ECO:0000269|PubMed:9389645}. |
| Top Pathways | Herpes simplex infection |