| Gene Symbol | PVR |
|---|---|
| Entrez Gene | 5817 |
| Alt Symbol | CD155, HVED, NECL5, Necl-5, PVS, TAGE4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | poliovirus receptor |
| Other Description | nectin-like protein 5 |
| Swissprots | Q96BJ1 P15151 Q15267 B4DTS9 P15152 Q15268 |
| Accessions | AAF69803 CAA45478 CAA45479 CAA45480 CBX51265 EAW57284 EAW57285 EAW57286 P15151 AI374885 AK025949 AK094177 BAG52836 AK098812 AK290946 BAF83635 AK300349 BAG62091 BC015542 AAH15542 BE838104 CA416069 DA849917 DC400059 DQ890969 ABM81895 DQ894143 ABM85069 M24406 AAA36462 M24407 AAA36461 XM_005259120 XP_005259177 NM_001135768 NP_001129240 NM_001135769 NP_001129241 NM_001135770 NP_001129242 NM_006505 NP_006496 |
| Function | Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing |
| Subcellular Location | Isoform Beta: Secreted. |
| Top Pathways | Cell adhesion molecules (CAMs) |