CNR1

Gene Symbol CNR1
Entrez Gene 1268
Alt Symbol CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR
Species Human
Gene Type protein-coding
Description cannabinoid receptor 1 (brain)
Other Description cannabinoid receptor 1|central cannabinoid receptor
Swissprots Q13949 E1P512 Q5JVL5 B2R9T4 Q5UB37 P21554 Q9UNN0 Q495Z0 Q4PLI4 Q4VBM6
Accessions AAB18200 AAG37765 AAO67710 AGS49222 EAW48574 EAW48575 EAW48576 P21554 AF107262 AAD34320 AK313908 BAG36631 AY766182 AAV35030 AY995204 AAY21179 BC074811 AAH74811 BC074812 AAH74812 BC095513 AAH95513 BC100968 AAI00969 BC100969 AAI00970 BC100970 AAI00971 BC100971 AAI00972 BM682178 BX538191 DA128033 DA239984 DA768458 DA793373 DA799263 DQ067455 AAY68486 KC292264 AGW25490 X54937 CAA38699 X81120 CAA57018 X81121 CAA57019 XM_005248650 XP_005248707 XM_006715330 XP_006715393 XM_011535424 XP_011533726 XM_011535425 XP_011533727 XM_011535426 XP_011533728 XM_011535427 XP_011533729 XM_011535428 XP_011533730 NM_001160226 NP_001153698 NM_001160258 NP_001153730 NM_001160259 NP_001153731 NM_016083 NP_057167 NM_033181 NP_149421 NM_001160260
Function Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. {ECO:0000269|PubMed:15620723}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:15620723}.
Top Pathways Retrograde endocannabinoid signaling, Rap1 signaling pathway, Neuroactive ligand-receptor interaction

CB1 (H-150) - sc-20754 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CB1 (H-150): sc-20754. Western blot analysis of CB1 expression in U-87 MG (A), RAW 264.7 (B) and IMR-32 (C) whole cell lysates and rat testis tissue extract (D).

CB1 (K-15) - sc-10068 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CB1 (K-15): sc-10068. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lung tissue showing cytoplasmic staining of pneumocytes and macrophages.

CB1 (N-15) - sc-10066 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CB1 (N-15): sc-10066. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lung tissue showing cytoplasmic staining of pneumocytes and macrophages.

p-CB1 (Ser 316) - sc-17555 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of CB1 phosphorylation in rat cerebellum tissue extract. Blots were probed with p-CB1 (Ser 316): sc-17555 preincubated with cognate non-phosphorylated (A) and cognate phosphorylated (B) peptides.

Anti-Cannabinoid Receptor I (phospho S316) antibody [EPR2223(N)] - ab186428 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2223(N)
All lanes : Anti-Cannabinoid Receptor I (phospho S316) antibody [EPR2223(N)] (ab186428) at 1/1000 dilutionLane 1 : Human fetal brain lysateLane 2 : Human fetal brain lysate with Lambda phosphataseLysates/proteins at 1/10 dilution per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Cannabinoid Receptor I antibody - ab3558 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab3558 at a 1:1000 dilution staining Rat CB1 in transfected AtT20 cells by immunocytochemistry.

Anti-Cannabinoid Receptor I antibody - ab137410 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Cannabinoid Receptor I antibody (ab137410) at 1/5000 dilution + Mouse brain whole cell lysate at 50 µg

Anti-Cannabinoid Receptor I antibody - ab75165 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cannabinoid Receptor I antibody (ab75165) at 1/500 dilutionLane 1 : extracts from COS-7cells Lane 2 : extracts from HT-29 cellsLane 3 : extracts from HT-29 cells with immunising peptide at 10ug Lysates/proteins at 30 µg per lane.

Anti-Cannabinoid Receptor I antibody - ab128226 from Abcam

Prices $372.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Cannabinoid Receptor I antibody - ab167366 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Cannabinoid Receptor I antibody (ab167366) at 1 µg/mlLane 1 : Cannabinoid Receptor I transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-Mouse IgG HRP at 1/2500 dilution

Anti-Cannabinoid Receptor I antibody [EPR2224(N)(B)] - ab172970 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2224(N)(B)
All lanes : Anti-Cannabinoid Receptor I antibody [EPR2224(N)(B)] (ab172970) at 1/1000 dilutionLane 1 : Human fetal brain lysatesLane 2 : HeLa cell lysatesLane 3 : SH-SY5Y lysatesLysates/proteins at 10 µg per lane.

Anti-CNR1 / CB1 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A31 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CNR1 / CB1 antibody LS-A31 IHC of human brain, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CNR1 / CB1 Antibody (C-Terminus) IHC-plus™ - LS-A32 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CNR1 / CB1 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CNR1 / CB1 Antibody (C-Terminus) - LS-C151379 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CNR1 / CB1 antibody Western Blot of Mouse Spleen.

Anti-CNR1 / CB1 Antibody (aa161-187) - LS-C157604 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
CB1 Antibody western blot of 293 cell line lysates (35 ug/lane). The CB1 antibody detected the CB1 protein (arrow).

Anti-CNR1 / CB1 Antibody (aa161-187, AP) - LS-C253452 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CNR1 / CB1 Antibody (aa161-187, APC) - LS-C253453 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CNR1 / CB1 Antibody (N-Terminus) - LS-C139792 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
CNR1 antibody (0.3 ug/ml) staining of Rat Brain lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-CNR1 / CB1 Antibody - LS-C137411 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CNR1 / CB1 Antibody (aa161-187, Biotin) - LS-C253454 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CNR1 / CB1 Antibody (aa161-187, FITC) - LS-C253455 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CNR1 / CB1 Antibody (clone 2F9) - LS-C196941 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F9
CNR1 monoclonal antibody (M01), clone 2F9. Western Blot analysis of CNR1 expression in rat testis.

Anti-CNR1 / CB1 Antibody (aa161-187, Azide-free, HRP) - LS-C253456 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CNR1 / CB1 Antibody (aa161-187, PE) - LS-C253457 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CNR1 / CB1 Antibody (N-Terminus) - LS-C139816 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
CNR1 antibody (1 ug/ml) staining of NIH3T3 lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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