ACACB

Gene Symbol ACACB
Entrez Gene 32
Alt Symbol ACC2, ACCB, HACC275
Species Human
Gene Type protein-coding
Description acetyl-CoA carboxylase beta
Other Description ACC-beta|acetyl-CoA carboxylase 2|acetyl-Coenzyme A carboxylase beta
Swissprots A6NK36 Q6TY48 Q16852 O00763 Q6KE89 Q1HEC1 Q6KE87
Accessions EAW97852 EAW97853 EAW97854 EAW97855 O00763 AB209110 BAD92347 AJ575431 CAE01470 AJ575592 CAE01471 AK302469 BAG63759 AK302502 BAG63782 AK307466 AY382667 AAR37018 AY701053 BC009753 BC028417 AAH28417 BC172264 AAI72264 BC172569 AAI72569 CB269093 CB269579 DB567934 DQ493870 ABF48723 HG505159 R99037 U34591 AAC50571 U89344 AAB58382 XM_005253876 XP_005253933 XM_006719365 XP_006719428 XM_006719367 XP_006719430 XM_011538259 XP_011536561 XM_011538260 XP_011536562 XM_011538261 XP_011536563 XM_011538262 XP_011536564 XM_011538263 XP_011536565 XM_011538264 XP_011536566 XM_011538265 XP_011536567 XR_944530 XR_944531 XR_944532 XR_944533 NM_001093 NP_001084
Function Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity). {ECO:0000250|UniProtKB:E9Q4Z2, ECO:0000269|PubMed:20952656}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:10677481}. Nucleus {ECO:0000269|PubMed:10677481}. Endomembrane system. Note=May associate with membranes.
Tissue Specificity Widely expressed with highest levels in heart, skeletal muscle, liver, adipose tissue, mammary gland, adrenal gland and colon (PubMed:9099716). Isoform 3 is expressed in skeletal muscle, adipose tissue and liver (at protein level) (PubMed:19190759). Isoform 3 is detected at high levels in adipose tissue with lower levels in heart, liver, skeletal muscle and testis (PubMed:19190759). {ECO:0000269|PubMed:19190759, ECO:0000269|PubMed:9099716}.
Top Pathways Glucagon signaling pathway, AMPK signaling pathway, Adipocytokine signaling pathway, Insulin signaling pathway, Pyruvate metabolism

Acetyl-CoA Carboxylase 2 (D5B9) Rabbit mAb - 8578 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5B9
Western blot analysis of extracts from human adipocytes using Acetyl-CoA Carboxylase 2 (D5B9) Rabbit mAb.

ACCβ (C-18) - sc-26821 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACCβ (C-18): sc-26821. Western blot analysis of ACCβ expression in human liver tissue extract.

ACCβ (H-220) - sc-50387 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ACCβ (H-220): sc-50387. Immunoperoxidase staining of formalin fixed, paraffin-embedded human upper stomach tissue showing cytoplasmic staining of glandular cells.

ACCβ (F-16) - sc-26820 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACCβ (F-16): sc-26820. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes.

Anti-ACACB / ACC2 Antibody (phospho-Ser221, clone EPR3143Y) - LS-C137712 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3143Y
IHC of paraffin-embedded human muscles using anti-ACACB antibody.

Anti-ACACB / ACC2 Antibody (aa217-231) IHC-plus™ - LS-B11360 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-ACACB / ACC2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11360 concentration 5 ug/ml.

Anti-ACACB / ACC2 Antibody (N-Terminus) - LS-C11716 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-ACACB / ACC2 Antibody (aa2261-2274) - LS-C54437 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ACACB / ACC2 Antibody (N-Terminus) - LS-C11717 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ACACB / ACC2 Antibody (aa146-159) - LS-C204960 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ACACB / ACC2 Antibody (clone 1C11) - LS-C196596 from LifeSpan Bioscience

Prices $355.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 1C11

Acetyl Coenzyme A Carboxylase Beta Antibody - NBP1-90274 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Acetyl Coenzyme A Carboxylase Beta Antibody [NBP1-90274] - Analysis in human adipose tissue.

Acetyl Coenzyme A Carboxylase Beta Antibody - NB100-59750 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Sandwich ELISA: Acetyl Coenzyme A Carboxylase Beta Antibody [NB100-59750] - Sandwich-type ELISA with increasing amount of recombinant ACACB captured by a rabbit antibody. Recommended reporter concentration: 1-2ug/ml

Acetyl Coenzyme A Carboxylase Beta Antibody (1C11) - H00000032-M01A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 1C11

Acetyl Coenzyme A Carboxylase Beta Antibody (3E8) - H00000032-M02A-200ul from Novus Biologicals

Prices $359.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 3E8

Anti-ACACB antibody produced in rabbit - HPA006554 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ACACB: <B>Cat. No. HPA006554</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver shows strong cytoplasmic positivity in hepatocytes.

Anti-ACACB antibody produced in goat - SAB2501935 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>ELISA</B><BR/>Anti-ACACB<B>Cat. No. SAB2501935</B>: Immunoblotting (1.5 μg/mL) as the reporter with SAB2501935 as the capture rabbit antibody (35 μg/mL).

ACACB-Antibody-internal-region - AF2572a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2572a (1.5ug/ml) as the reporter with EB002020 as the capture rabbit antibody (5ug/ml).

ACACB-mouse-Antibody-internal-region - AF3636a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

ACACB-aa146-159-Antibody-internal-reion-near-N-Term - AF3635a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

ACACB antibody, Internal - GTX89089 from GeneTex

Prices $319.00
Sizes 100 μg
Host Goat
Clonality Polyclonal
Anti-ACACB antibody, Internal used in ELISA. GTX89089

Anti -ACACB (Acetyl-CoA Carboxylase 2, ACC-beta, ACC2, ACCB) - A0224-03C from USBiological Life Science

Host Goat
Clonality Polyclonal

Anti -ACACB (Acetyl-CoA Carboxylase 2, ACC-beta, ACC2, ACCB) - 122843 from USBiological Life Science

Host Mouse
Clonality Monoclonal
Clone 1C11

Anti -ACACB (Acetyl-CoA Carboxylase 2, ACC-beta, ACC2, ACCB) (AP) - A0224-03C-AP from USBiological Life Science

Host Goat
Clonality Polyclonal

Anti -ACACB (Acetyl-CoA Carboxylase 2, ACC-beta, ACC2, ACCB) (APC) - A0224-03C-APC from USBiological Life Science

Host Goat
Clonality Polyclonal
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