| Gene Symbol | PPP2R1A |
|---|---|
| Entrez Gene | 5518 |
| Alt Symbol | PP2A-Aalpha, PP2AAALPHA, PR65A |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 2, regulatory subunit A, alpha |
| Other Description | PP2A subunit A isoform PR65-alpha|PP2A subunit A isoform R1-alpha|medium tumor antigen-associated 61 KDA protein|protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform|serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform|serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform |
| Swissprots | Q6ICQ3 Q13773 Q96DH3 P30153 |
| Accessions | AAA35531 EAW72066 P30153 AK090488 BAG52168 AK091387 BAC03652 AK130000 AK290593 BAF83282 AK291932 BAF84621 AK293174 BAG56718 AK293493 BAG56980 AK299012 BAG61093 AK303934 BAG64862 AK307743 AK315700 BAG38062 AU128747 BC001537 AAH01537 BC026733 BT008074 AAP36766 CA426613 CR450340 CAG29336 DB246691 DC398468 DQ892756 ABM83682 DQ896000 ABM86978 J02902 AAA36399 NM_014225 NP_055040 NR_033500 |
| Function | The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis. {ECO:0000269|PubMed:16580887}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Chromosome, centromere {ECO:0000269|PubMed:16580887}. Note=Centromeric localization requires the presence of BUB1. |
| Top Pathways | Sphingolipid signaling pathway, Adrenergic signaling in cardiomyocytes, AMPK signaling pathway, Hippo signaling pathway, TGF-beta signaling pathway |