| Gene Symbol |
PHIP
|
| Entrez Gene |
55023
|
| Alt Symbol |
BRWD2, DCAF14, WDR11, ndrp
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pleckstrin homology domain interacting protein
|
| Other Description |
DDB1 and CUL4 associated factor 14|IRS-1 PH domain-binding protein|PH-interacting protein|WD repeat-containing protein 11
|
| Swissprots |
Q5VVH4 A7J992 Q66I29 Q69YV1 Q96ME2 Q9H261 Q8WWQ0 Q05CQ9 B2RPK4 Q8NBZ5 Q96H52
|
| Accessions |
EAW48717 EAW48718 EAW48719 Q8WWQ0 AF310250 AAG45145 AJ303102 CAC83118 AK000712 BAA91336 AK057039 BAB71353 AK075124 BAC11417 AK127816 AL049321 AL161957 CAH10776 BC008909 AAH08909 BC021905 AAH21905 BC036479 BC064611 BC081569 AAH81569 BC137488 AAI37489 BC144670 BI548935 BX537762 DA500781 DQ924532 ABK76299 XM_005248729 XP_005248786 XM_011535917 XP_011534219 XM_011535918 XP_011534220 XM_011535919 XP_011534221 XR_942499 NM_017934 NP_060404
|
| Function |
Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti- apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expressed in myeloma and epidermoid carcinoma cell lines. {ECO:0000269|PubMed:11018022}.
|