Acot1

Gene Symbol Acot1
Entrez Gene 26897
Alt Symbol ACH2, CTE-1, CTE-I, Cte1, D12Ucla1
Species Mouse
Gene Type protein-coding
Description acyl-CoA thioesterase 1
Other Description acyl-CoA thioesterase 1, cytosolic|acyl-coenzyme A thioesterase 1|cytosolic acyl-CoA thioesterase 1|inducible cytosolic acyl-coenzyme A thioester hydrolase|long chain acyl-CoA hydrolase|long chain acyl-CoA thioester hydrolase
Swissprots Q549A9 O55137
Accessions AAF13870 O55137 AK053680 BC003911 AAH03911 BC022951 BC028261 AAH28261 BC040749 Y14004 CAA74327 NM_012006 NP_036136
Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. True acyl-CoA thioesterase being highly specific for saturated C12-C20 acyl-CoAs, with only a very low activity with decanoyl-CoA as substrate. Most active on myristoyl- and palmitoyl-CoA. Introduction of one or two double bonds decreases the activity to about half. No detectable activity with bile acid CoAs such as choloyl-CoA and chenodeoxycholoyl-CoA. {ECO:0000269|PubMed:10567408}.
Subcellular Location Cytoplasm.
Tissue Specificity Expressed in heart, kidney, brown adipose tissue, white adipose tissue, adrenal gland and muscle. {ECO:0000269|PubMed:10567408, ECO:0000269|PubMed:11330065}.
Top Pathways Fatty acid elongation, Biosynthesis of unsaturated fatty acids

Mouse Acot1 ORF Clone(NM_012006.2) - CDCL152928 from Creative Biomart

Species Mouse
Accession NM_012006.2

Mouse Acot1 ORF Clone(NM_012006.2) - CDCR251395 from Creative Biomart

Species Mouse
Accession NM_012006.2

Mouse Acot1 ORF Clone(NM_012006.2) - CDCR251396 from Creative Biomart

Species Mouse
Accession NM_012006.2

Mouse Acot1 ORF clone (NM_012006.2) - CDCR023808 from Creative biogene

Species Mouse
Search more