| Gene Symbol |
Scrib
|
| Entrez Gene |
105782
|
| Alt Symbol |
AI118201, CRIB, Crc, SCRIB1, Scrb1, mKIAA0147, vartul
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
scribbled homolog (Drosophila)
|
| Other Description |
PDZ-domain protein scribble|circletail|protein scribble homolog|scribble homolog 1
|
| Swissprots |
Q8VII1 Q6P5H7 Q7TPH8 Q922S3 Q8CI48 Q80VB1 Q80U72
|
| Accessions |
EDL29514 EDL29515 EDL29516 EDL29517 EDL29518 EDL29519 Q80U72 AF271735 AAP88019 AF441233 AAL32469 AK122211 BAC65493 AK205808 BC006859 AAH06859 BC037480 AAH37480 BC049942 AAH49942 BC060689 AAH60689 BC062888 AAH62888 DQ704151 XM_006520238 XP_006520301 XM_006520239 XP_006520302 XM_006520240 XP_006520303 XM_006520241 XP_006520304 XM_006520242 XP_006520305 XR_875207 XR_875208 NM_134089 NP_598850
|
| Function |
Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity. {ECO:0000269|PubMed:12499390, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:19458197}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Found in a wide range of tissues including liver, brain, kidney and spleen. {ECO:0000269|PubMed:15806148}.
|
| Top Pathways |
Viral carcinogenesis, Hippo signaling pathway
|