| Gene Symbol |
Tesc
|
| Entrez Gene |
57816
|
| Alt Symbol |
1010001A17Rik, 2410011K10Rik, TE-1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
tescalcin
|
| Other Description |
CHP3|TSC|calcineurin B homologous protein 3
|
| Swissprots |
Q8VCN1 Q32Q85 Q9JKL5
|
| Accessions |
EDL19800 Q9JKL5 AF234783 AAF40439 AK010463 BC019492 AAH19492 BC107679 AAI07680 GQ856259 ACX32051 GQ856260 ACX32052 GQ856261 ACX32053 XR_387574 NM_021344 NP_067319
|
| Function |
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. {ECO:0000269|PubMed:14661968}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Membrane. Cell membrane {ECO:0000250}. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Colocalizes with SLC9A1 at the cell membrane. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in embryonic, newborn and adult testis, but not in prepubertal testis. Expressed in the embryonic testis during testis determination but is not expressed at any time in the embryonic ovary. In embryonic testis, expression is restricted to the testis cords and is seen in both Sertoli cells and germ cells. Expression is excluded from the myoid cells which surround the cords. Expressed in the embryonic adrenal after the initial stages of differentiation. Expressed at a lower level in the embryonic brain, heart and lung but not in liver or gut. May be expressed at a very low level in the embryonic kidney. In the embryonic brain, expressed in the nasal placode and in fibers extending from the olfactory epithelium to the primordial olfactory bulb. In adults, expressed in the heart, and weakly in the brain and kidney. Highly expressed in terminally differentiated megakaryocytes (at protein level). Not detected in fetal liver cells (at protein level). {ECO:0000269|PubMed:11145610, EC
|