| Gene Symbol | CD14 |
|---|---|
| Entrez Gene | 929 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD14 molecule |
| Other Description | monocyte differentiation antigen CD14|myeloid cell-specific leucine-rich glycoprotein |
| Swissprots | Q9UNS3 Q53XT5 Q96L99 P08571 Q96FR6 |
| Accessions | AAA20640 ADX31876 CAA29999 EAW62037 P08571 AB446505 BAG55282 AF097942 AAC83816 AK313277 BAG36085 AM392692 CAL37570 AM392824 CAL37702 AM393386 CAL38264 AM393697 CAL38573 AY044269 AAL02401 BC010507 AAH10507 BP300412 BT007331 AAP35995 CF593452 DA269805 DA426297 DA681405 M86511 AAA51930 W74441 X13334 CAA31711 NM_000591 NP_000582 NM_001040021 NP_001035110 NM_001174104 NP_001167575 NM_001174105 NP_001167576 |
| Function | In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. {ECO:0000269|PubMed:23264655}. |
| Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
| Tissue Specificity | Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages. |
| Top Pathways | Legionellosis, Tuberculosis, Salmonella infection, Amoebiasis, Pertussis |