| Gene Symbol |
RICTOR
|
| Entrez Gene |
253260
|
| Alt Symbol |
AVO3, PIA, hAVO3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RPTOR independent companion of MTOR, complex 2
|
| Other Description |
AVO3 homolog|TORC2-specific protein AVO3|pianissimo|rapamycin-insensitive companion of mTOR
|
| Swissprots |
Q8N3A0 Q86UB7 B2RNX0 Q6R327 Q68DT5 B7ZMF7 Q8NCM6
|
| Accessions |
EAW55978 EAW55979 EAW55980 Q6R327 AB082530 BAC02708 AK024327 AK094538 AK127305 AK128358 AL834497 CAD39155 AY515854 AAS79796 BC029608 AAH29608 BC051729 AAH51729 BC137163 AAI37164 BC137164 AAI37165 BC144509 AAI44510 BP245264 CN478622 CR749280 CAH18135 DQ891672 ABM82598 DQ894858 ABM85784 XM_006714463 XP_006714526 XM_011514005 XP_011512307 XM_011514006 XP_011512308 XM_011514007 XP_011512309 NM_001285439 NP_001272368 NM_001285440 NP_001272369 NM_152756 NP_689969
|
| Function |
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. {ECO:0000269|PubMed:15268862, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15718470}.
|
| Top Pathways |
mTOR signaling pathway
|