CACNB2
| Gene Symbol | CACNB2 |
|---|---|
| Entrez Gene | 783 |
| Alt Symbol | CACNLB2, CAVB2, MYSB |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium channel, voltage-dependent, beta 2 subunit |
| Other Description | CAB2|calcium channel voltage-dependent subunit beta 2|lambert-Eaton myasthenic syndrome antigen B|myasthenic (Lambert-Eaton) syndrome antigen B|voltage-dependent L-type calcium channel subunit beta-2 |
| Swissprots | Q6TME3 Q9Y341 Q5VWV6 A6PVM8 A6PVM5 Q96NZ4 A6PVM7 Q9Y340 Q6TME1 O00304 Q6TME2 Q96NZ3 Q5QJA0 Q5QJ99 Q8WX81 Q5VVG9 Q96NZ5 Q5VVH0 Q9BWU2 Q08289 Q9HD32 |
| Accessions | AAB27916 AAK16994 EAW86193 EAW86194 EAW86195 EAW86196 EAW86197 Q08289 AB208917 BAD92154 AF137376 AAD33729 AF137377 AAD33730 AF285239 AAG01473 AF423189 AAL16948 AF423190 AAL16949 AF423191 AAL16950 AF423192 AAL16951 AF465485 AAL73495 AK021994 AK022426 AK128769 AK293837 BAH11608 AK293937 BAH11631 AK295113 BAH11979 AK296471 BAH12366 AK299873 BAH13158 AK307526 AK307800 AK310943 AK311694 AL119895 AL599294 AL600557 AY393858 AAQ97606 AY393859 AAQ97607 AY393860 AAQ97608 AY393861 AAQ97609 AY393862 AAQ97610 AY393863 AAQ97611 AY675091 AAV49501 AY675092 AAV49502 BC136409 AAI36410 BM312516 DB235418 DC307859 DC352526 S60415 AAB51370 U95019 AAB53332 XM_005252588 XP_005252645 XM_005252591 XP_005252648 XM_006717502 XP_006717565 XM_011519659 XP_011517961 XM_011519660 XP_011517962 NM_000724 NP_000715 NM_001167945 NP_001161417 NM_201570 NP_963864 NM_201571 NP_963865 NM_201572 NP_963866 NM_201590 NP_963884 NM_201593 NP_963887 NM_201596 NP_963890 NM_201597 NP_963891 |
| Function | The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. |
| Subcellular Location | Cell membrane, sarcolemma {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. |
| Tissue Specificity | Expressed in all tissues. |
| Top Pathways | MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
L-type Ca ++ CP β2 siRNA (h) - sc-90812 from Santa Cruz Biotechnology
|
||||||||
L-type Ca ++ CP β2 shRNA Plasmid (h) - sc-90812-SH from Santa Cruz Biotechnology
|
||||||||
L-type Ca ++ CP β2 shRNA (h) Lentiviral Particles - sc-90812-V from Santa Cruz Biotechnology
|
||||||||
CACNB2 RNAi - H00000783-R02 from Novus Biologicals
|
||||||||
CACNB2 RNAi - H00000783-R06 from Novus Biologicals
|
||||||||
CACNB2 RNAi - H00000783-R07 from Novus Biologicals
|
||||||||
CACNB2 RNAi - H00000783-R05 from Novus Biologicals
|
||||||||
CACNB2 RNAi - H00000783-R03 from Novus Biologicals
|
||||||||
CACNB2 RNAi - H00000783-R01 from Novus Biologicals
|
||||||||
CACNB2 RNAi - H00000783-R08 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU124941 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN5270 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5270 from Sigma-Aldrich
|
||||||||
CACNB2 siRNA (Human) - CRH0548 from Cohesion Biosciences
|
||||||||
CACNB2 RNAi - H00000783-R04 from Novus Biologicals
|
||||||||
CACNB2 - MBS8237157 from MyBioSource
|
||||||||
shRNA set against Human CACNB2 (NM_000724.3) - SHH253429 from Creative biogene
|
||||||||
shRNA set against Human CACNB2(NM_201597.2) - SHG132103 from Creative biogene
|
||||||||
shRNA set against Human CACNB2(NM_201590.2) - SHG132139 from Creative biogene
|
||||||||
shRNA set against Human CACNB2(NM_201593.2) - SHG132193 from Creative biogene
|
||||||||
shRNA set against Human CACNB2(NM_000724.3) - SHG132245 from Creative biogene
|
||||||||
shRNA set against Human CACNB2(NM_201596.2) - SHG132337 from Creative biogene
|
||||||||
shRNA set against Human CACNB2(NM_201570.2) - SHG132481 from Creative biogene
|
||||||||
Human CACNB2 siRNA - orb261050 from Biorbyt
|
||||||||
CACNB2 shRNA Plasmid (Human) - CHH0548 from Cohesion Biosciences
|