XRCC3

Gene Symbol	XRCC3
Entrez Gene	7517
Alt Symbol	CMM6
Species	Human
Gene Type	protein-coding
Description	X-ray repair complementing defective repair in Chinese hamster cells 3
Other Description	DNA repair protein XRCC3|X-ray repair cross-complementing protein 3
Swissprots	Q9BU18 O43542 O43568
Accessions	AAC04805 AAM23015 CAE90683 CAE91829 EAW81837 EAW81838 EAW81839 EAW81840 EAW81841 EAW81842 O43542 AF035586 AAC05368 AK022829 BAG51121 AK023646 BAG51212 AK124498 BAG54042 AK126706 BC001036 AAH01036 BC002949 AAH02949 BC011725 AAH11725 BC073820 BT007417 AAP36085 BX161398 CAD61884 DB041321 DQ892162 ABM83088 DQ895355 ABM86281 XM_005268046 XP_005268103 XM_011537138 XP_011535440 NM_001100118 NP_001093588 NM_001100119 NP_001093589 NM_005432 NP_005423
Function	Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. {ECO:0000269|PubMed:14716019, ECO:0000269|PubMed:20413593, ECO:0000269|Pu
Subcellular Location	Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.
Top Pathways	Homologous recombination

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human XRCC3 full length protein - ab139221 from Abcam Category Protein Source E. coli Species Human

XRCC3 Antibody Blocking Peptide - LS-E22407 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XRCC3 Antibody Blocking Peptide - LS-E22408 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XRCC3 Recombinant Protein - H00007517-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

XRCC3 Partial Recombinant Protein - H00007517-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human XRCC3 Protein - NBP2-22953 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Human XRCC3 protein - orb246467 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

XRCC3 Blocking Peptide - 33R-4808 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

XRCC3 Blocking Peptide - 33R-4760 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

XRCC3 protein (His tag) - 30R-2940 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

XRCC3 Blocking Peptide - abx063430 from Abbexa Category Peptide Species Human

XRCC3 (1-346, His-tag) - AR50700PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

XRCC3 (1-346, His-tag) - AR50700PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

XRCC3 - H00007517-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

XRCC3 - H00007517-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

XRCC3 - H00007517-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

XRCC3 - H00007517-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

XRCC3, 1-346aa, Human, His tag, E.coli - 01-P1876 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

XRCC3 fusion protein - ag13317 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Human XRCC3 Recombinant Protein - GWB-PPAT38 from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human XRCC3, T7-tagged - XRCC3-3057H from Creative Biomart Category Protein Source E.Coli.

Recombinant Human XRCC3, T7 -tagged - XRCC3-30133TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human XRCC3, His-tagged - XRCC3-7094H from Creative Biomart Category Protein Source E. coli Species Human

XRCC3 Blocking Peptide - CBP2236 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

XRCC3 (Q67) Peptide - BS1495P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Search more