| Gene Symbol |
GPRC5A
|
| Entrez Gene |
9052
|
| Alt Symbol |
GPCR5A, PEIG-1, RAI3, RAIG1, TIG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor, class C, group 5, member A
|
| Other Description |
G protein-coupled receptor, family C, group 5, member A|G-protein coupled receptor family C group 5 member A|TPA induced gene 1|orphan G-protein-coupling receptor PEIG-1|phorbol ester induced protein-1|retinoic acid induced 3|retinoic acid responsive|retinoic acid-induced gene 1 protein|retinoic acid-induced protein 3
|
| Swissprots |
O95357 Q8NFJ5 B3KV45
|
| Accessions |
EAW96289 Q8NFJ5 AF095448 AAC98506 AF506289 AAM77594 AI587426 AK001761 BAA91890 AK122672 BAG53657 AK172760 AK291171 BAF83860 BC003665 AAH03665 BE519991 NM_003979 NP_003970
|
| Function |
Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles.
|
| Tissue Specificity |
Expressed at high level in fetal and adult lung tissues. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart. {ECO:0000269|PubMed:10783259, ECO:0000269|PubMed:10945465}.
|
![Western Blot: RAI3 Overexpression Lysate (Adult Normal) [NBL1-11303] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RAI3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1509_RAI3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11303-img0002.jpg)