CHRM2

Gene Symbol	CHRM2
Entrez Gene	1129
Alt Symbol	HM2
Species	Human
Gene Type	protein-coding
Description	cholinergic receptor, muscarinic 2
Other Description	7TM receptor|acetylcholine receptor, muscarinic 2|muscarinic M2 receptor|muscarinic acetylcholine receptor M2
Swissprots	Q9P1X9 Q4VBK6 P08172
Accessions	AAA51570 BAA94476 CAA33335 CBJ06536 EAL24054 EAW83865 EAW83866 P08172 AF385588 AAK68113 AF498916 AAM18939 AK125233 AK290236 BAF82925 AL832585 AM393517 CAL38394 AY034603 AAO23567 AY034604 AAO23568 AY034605 AAO23569 AY219703 AAO65595 AY219704 AAO65596 AY219705 AAO65597 AY456125 AAR14890 AY456126 AAR14891 AY456127 AAR14892 AY456128 AAR14893 AY456129 AAR14894 BC095547 AAH95547 BC106741 AAI06742 BC106742 AAI06743 XM_011515769 XP_011514071 XM_011515770 XP_011514072 XM_011515771 XP_011514073 NM_000739 NP_000730 NM_001006626 NP_001006627 NM_001006627 NP_001006628 NM_001006628 NP_001006629 NM_001006629 NP_001006630 NM_001006630 NP_001006631 NM_001006631 NP_001006632 NM_001006632 NP_001006633 NM_001006633
Function	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250}.
Top Pathways	Calcium signaling pathway, PI3K-Akt signaling pathway, cAMP signaling pathway, Regulation of actin cytoskeleton, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Muscarinic Acetylcholine Receptor 2 protein fragment - ab152277 from Abcam Category Protein Source Wheat germ Species Human

CHRM2 / M2 Antibody Blocking Peptide - LS-E3267 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHRM2 / M2 Antibody Blocking Peptide - LS-E28410 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CHRM2 / M2 Antibody Blocking Peptide - LS-E28238 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CHRM2 / M2 Antibody Blocking Peptide - LS-E28239 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CHRM2 / M2 Antibody Blocking Peptide - LS-E28240 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CHRM2 / M2 Antibody Blocking Peptide - LS-E27942 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Muscarinic Acetylcholine Receptor M2/CHRM2 Protein - H00001129-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Muscarinic Acetylcholine Receptor M2/CHRM2 Protein - H00001129-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

CHRM2-Antibody-Center-Blocking-Peptide - BP14420c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ChRM2 peptide - orb72527 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

Muscarinic Acetylcholine Receptor 2 Peptide - AC21-2711-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Muscarinic acetylcholine receptor M2 - H00001129-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

Muscarinic acetylcholine receptor M2 - H00001129-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Muscarinic acetylcholine receptor M2 - H00001129-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CHRM2 Peptide - 43-080P from ProSci Category Peptide Species Mouse

CHRM2 fusion protein - ag15859 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CHRM2 fusion protein - ag15933 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human CHRM2 - CHRM2-175H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Cholinergic Receptor, Muscarinic 2 (CHRM2) - RPB213Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Cholinergic Receptor, Muscarinic 2 (CHRM2) - RPB213Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cholinergic Receptor, Muscarinic 2 (CHRM2) - RPB213Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cholinergic Receptor, Muscarinic 2 (CHRM2) - RPB213Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

ChemiSCREEN™ Membrane Preparation Recombinant Human M 2 Muscarinic Acetylcholine Receptor - HTS115M from EMD Millipore Prices $596.00 Sizes 200 units Species Human

mAChR M2 (P224) Peptide - BS2781P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

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