CCP110

Gene Symbol CCP110
Entrez Gene 9738
Alt Symbol CP110, Cep110
Species Human
Gene Type protein-coding
Description centriolar coiled coil protein 110kDa
Other Description centriolar coiled-coil protein of 110 kDa|centrosomal protein CP110|centrosomal protein of 110 kDa
Swissprots Q68DV9 O43335 B7WP23 Q8NE13 O43303
Accessions AAC05804 EAW50287 EAW50288 O43303 AB007879 BAA24849 AK300426 BAG62153 AK309196 BC030223 BC034140 BC036654 AAH36654 BP360952 BQ632514 BY798911 CB066937 CN307903 CN307908 CR749255 CAH18111 DA250590 DA370828 DB504255 DQ891266 ABM82192 DQ894454 ABM85380 XM_005255719 XP_005255776 XM_011545991 XP_011544293 XM_011545992 XP_011544294 XM_011545993 XP_011544295 NM_001199022 NP_001185951 NM_014711 NP_055526
Function Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. {ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:21620453}. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis.
Tissue Specificity Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:12361598}.

Panoply™ Human CCP110 Knockdown Stable Cell Line - CSC-DC002668 from Creative biogene

Category Cell Line
Species Human

CCP110 KO Cell Lysate-HEK293T - CLKO-1008 from Creative biogene

Category Cell Lysate
Search more