TJP2

Gene Symbol	TJP2
Entrez Gene	9414
Alt Symbol	C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2
Species	Human
Gene Type	protein-coding
Description	tight junction protein 2
Other Description	Friedreich ataxia region gene X104 (tight junction protein ZO-2)|tight junction protein ZO-2|zona occludens 2|zonula occludens protein 2
Swissprots	Q5VXL0 A2A3H9 Q5VXL1 Q9UDY2 Q9UDY1 Q99839 B7Z7T6 B7Z2R8 F5H886 Q9UDY0 F5H301 Q8NI14 Q8N756 Q15883
Accessions	AAC02527 AAD20387 AAD56218 AAD56219 EAW62476 EAW62477 EAW62478 EAW62479 EAW62480 Q9UDY2 AA724570 AF083892 AAC33121 AF083893 AAC33122 AF489824 AAM28524 AI738923 AK025185 AK295016 BAH11949 AK295034 BAH11954 AK302483 BAH13722 AK304447 BAH14190 AK307697 AK308564 AM392689 CAL37567 AM392712 CAL37590 AM392803 CAL37681 AM392967 CAL37845 BC027592 AAH27592 BC028426 CX865985 DA270962 DB090695 DB196171 DC325189 L27476 AAA61300 U84581 AAB41794 XM_005252314 XP_005252371 XM_006717324 XP_006717387 XM_011519204 XP_011517506 XM_011519205 XP_011517507 XM_011519206 XP_011517508 XM_011519207 XP_011517509 XM_011519208 XP_011517510 XM_011519209 XP_011517511 NM_001170414 NP_001163885 NM_001170415 NP_001163886 NM_001170416 NP_001163887 NM_001170630 NP_001164101 NM_004817 NP_004808 NM_201629 NP_963923
Function	Plays a role in tight junctions and adherens junctions.
Subcellular Location	Cell junction, adherens junction. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Nucleus {ECO:0000250}. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. {ECO:0000250}.
Tissue Specificity	This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. {ECO:0000269|PubMed:11018256}.
Top Pathways	Tight junction, Vibrio cholerae infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ZO-2 Antibody - 2847 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

ZO-2 (C-16) - sc-12386 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ZO-2 (H-110) - sc-11448 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

ZO-2 (R-19) - sc-8148 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-TJP2 antibody - ab186951 from Abcam Host Rabbit Clonality Polyclonal

Anti-TJP2 antibody - ab130663 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody - LS-C26436 from LifeSpan Bioscience Prices $485.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (Internal) - LS-C26437 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (Internal) - LS-C26438 from LifeSpan Bioscience Prices $495.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (aa411-467) - LS-C124821 from LifeSpan Bioscience Prices $620.00 Sizes 100 µg Host Guinea Pig Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (aa411-467) - LS-C140252 from LifeSpan Bioscience Prices $515.00 Sizes 100 µg Host Guinea Pig Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (phospho-Ser978) - LS-C158656 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (aa468-517) - LS-C80535 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (C-Terminus) - LS-C80536 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (aa980-1009, AP) - LS-C271542 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (aa980-1009, APC) - LS-C271543 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (aa980-1009, Biotin) - LS-C271544 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (aa980-1009, Azide-free, HRP) - LS-C271546 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (Gln1112) - LS-C177406 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (phospho-Ser978, AP) - LS-C271547 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (aa980-1009, PE) - LS-C271548 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (phospho-Ser978, Biotin) - LS-C271549 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (phospho-Ser978, APC) - LS-C271550 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (phospho-Ser978, FITC) - LS-C271551 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TJP2 / ZO2 / ZO-2 Antibody (phospho-Ser978, Azide-free, HRP) - LS-C271552 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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