ERBB4

Gene Symbol ERBB4
Entrez Gene 2066
Alt Symbol ALS19, HER4, p180erbB4
Species Human
Gene Type protein-coding
Description erb-b2 receptor tyrosine kinase 4
Other Description avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4|human epidermal growth factor receptor 4|proto-oncogene-like protein c-ErbB-4|receptor tyrosine-protein kinase erbB-4|tyrosine kinase-type cell surface receptor HER4|v-erb-a erythroblastic leukemia viral oncogene homolog 4|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
Swissprots Q59EW4 B7ZLD7 Q2M1W1 B7ZLE3 Q15303 B7ZLE2
Accessions AAX82011 AAX88856 AAY14899 AAY15092 AAY24158 AAY24303 CAJ55818 CCQ43309 EAW70496 EAW70497 EAW70498 Q15303 AB209697 BAD92934 AF007153 AI793060 AK024204 AK126298 AK308606 BC112199 AAI12200 BC143741 AAI43742 BC143747 AAI43748 BC143749 AAI43750 BQ015804 CR627023 L07868 AAB59446 XM_005246375 XP_005246432 XM_005246376 XP_005246433 XM_005246377 XP_005246434 XM_006712364 XP_006712427 NM_001042599 NP_001036064 NM_005235 NP_005226
Function Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alter
Subcellular Location Cell membrane {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}; Single-pass type I membrane protein {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19193720, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}. Note=In response to NRG1 treatment, the activated receptor is internalized.
Tissue Specificity Expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. Lower levels in thymus, lung, salivary gland, and pancreas. Isoform JM-A CYT-1 and isoform JM-B CYT-1 are expressed in cerebellum, but only the isoform JM-B is expressed in the heart. {ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:9334263}.
Top Pathways ErbB signaling pathway, Calcium signaling pathway, Endocytosis, Proteoglycans in cancer

Mouse ErbB4/Her4 (NP_034284) VersaClone cDNA - RDC0940 from R&D Systems

Prices $799.00
Sizes 10 µg
Species Mouse

ERBB4 - MBS1277448 from MyBioSource

Species Human
Accession BC112199

Human ERBB4 cDNA clone(NM_001042599.1) - CDFH006046 from Creative Biomart

Species Human
Accession NM_001042599.1

Human ERBB4 ORF Clone(NM_001042599.1) - CDCR344652 from Creative Biomart

Species Human
Accession NM_001042599.1

Human ERBB4 ORF Clone(NM_001042599.1) - CDCR344653 from Creative Biomart

Species Human
Accession NM_001042599.1

Human ERBB4 ORF Clone(NM_001042599.1) - CDCR344654 from Creative Biomart

Species Human
Accession NM_001042599.1

Human ERBB4 ORF Clone(NM_005235.2) - CDCL162546 from Creative Biomart

Species Human
Accession NM_005235.2

Human ErbB4 ORF clone(NM_001042599.1) - CDCL184104 from Creative Biomart

Species Human
Accession NM_001042599.1

Human ErbB4/Her4 (NP_005226) VersaClone cDNA - RDC1302 from R&D Systems

Prices $799.00
Sizes 10 µg
Species Human

Human ErbB4 ORF clone(NM_001042599.1) - CDCL184104 from Creative biogene

Species Human

Human ERBB4 ORF Clone (BC112199) - CDCS407131 from Creative biogene

Species Human
Accession Q15303

Human ERBB4 cDNA Clone(NM_001042599.1) - CDFH006046 from Creative biogene

Species Human
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