PTGS2

Gene Symbol	PTGS2
Entrez Gene	282023
Alt Symbol	-
Species	Bovine
Gene Type	protein-coding
Description	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Other Description	COX-2\|PGH synthase 2\|PGHS-2\|PHS II\|cyclooxygenase-2\|prostaglandin G/H synthase 2\|prostaglandin H2 synthase 2
Swissprots	O62698 O46517 O62665
Accessions	AAC28562 DAA20948 O62698 AF004944 AAC05592 AF031698 AAC04702 AF145750 AAD33956 XM_010813539 XP_010811841 XM_010813540 XP_010811842 NM_174445 NP_776870
Function	Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis (By similarity). {ECO:0000250}.
Subcellular Location	Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Top Pathways	Chemical carcinogenesis, Leishmaniasis, Retrograde endocannabinoid signaling, TNF signaling pathway, Ovarian steroidogenesis

Search more