| Gene Symbol |
Arhgef2
|
| Entrez Gene |
310635
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
rho/rac guanine nucleotide exchange factor (GEF) 2
|
| Other Description |
GEF-H1|guanine nucleotide exchange factor H1|rho guanine nucleotide exchange factor 2
|
| Swissprots |
Q5FVC2
|
| Accessions |
Q5FVC2 BC090078 AAH90078 FQ212011 XM_006232643 XP_006232705 XM_006232644 XP_006232706 XM_006232646 XP_006232708 XM_006232647 XP_006232709 XM_006232648 XP_006232710 XM_006232651 XP_006232713 XM_006232652 XP_006232714 XM_006232653 XP_006232715 XM_006232654 XP_006232716 XM_008761151 XP_008759373 XM_008761152 XP_008759374 NM_001012079 NP_001012079
|
| Function |
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2 (By similarity).
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization. Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (By similarity). {ECO:0000250}.
|