PRKX

Gene Symbol PRKX
Entrez Gene 5613
Alt Symbol PKX1
Species Human
Gene Type protein-coding
Description protein kinase, X-linked
Other Description cAMP-dependent protein kinase catalytic subunit PRKX|protein kinase PKX1|protein kinase X|protein kinase X-linked|serine/threonine-protein kinase PRKX
Swissprots P51817
Accessions CBX55118 EAW98726 EAW98727 EAW98728 P51817 BC041073 AAH41073 BE675757 DN996851 DN997580 EU832357 ACE87614 EU832442 ACE86927 X85545 CAA59733 XM_005274560 XP_005274617 XM_005274561 XP_005274618 XM_011545544 XP_011543846 NM_005044 NP_005035
Function Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. {ECO:0000269|PubMed:12082174, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:17980165, ECO:0000269|PubMed:19367327, ECO:0000269|PubMed:21684272, ECO:0000269|PubMed:9860982}.
Subcellular Location Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation.
Tissue Specificity Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982. {ECO:0000269|PubMed:15879576, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:7633447, ECO:0000269|PubMed:9860982}.
Top Pathways Adrenergic signaling in cardiomyocytes, Ovarian steroidogenesis, Wnt signaling pathway, Proteoglycans in cancer, Estrogen signaling pathway

PRKX CRISPR/Cas9 KO Plasmid (h) - sc-410956 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRKX HDR Plasmid (h) - sc-410956-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRKX Double Nickase Plasmid (h) - sc-410956-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRKX Double Nickase Plasmid (h2) - sc-410956-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRKX CRISPR Activation Plasmid (h) - sc-410956-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRKX CRISPR Activation Plasmid (h2) - sc-410956-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRKX Lentiviral Activation Particles (h) - sc-410956-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRKX Lentiviral Activation Particles (h2) - sc-410956-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRKX siRNA (h) - sc-106447 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PRKX shRNA Plasmid (h) - sc-106447-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PRKX shRNA (h) Lentiviral Particles - sc-106447-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU107821 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1872 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1870 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1871 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN17432 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17432 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PRKX siRNA (Human) - CRH3783 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PRKX RNAi - H00005613-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human PRKX (NM_005044.4) - SHH383020 from Creative biogene

Category siRNA
Species Reactivities Human

PRKX shRNA Plasmid (Human) - CHH3783 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PRKX miRNA 3'UTR clone - MiUTR4H-TG07054 from Creative biogene

Species Reactivities Human
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