PPP1CB

Gene Symbol	PPP1CB
Entrez Gene	5500
Alt Symbol	HEL-S-80p, PP-1B, PP1B, PP1beta, PPP1CD
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 1, catalytic subunit, beta isozyme
Other Description	epididymis secretory sperm binding protein Li 80p|protein phosphatase 1, catalytic subunit, beta isoform|protein phosphatase 1, catalytic subunit, delta isoform|protein phosphatase 1-beta|protein phosphatase 1-delta|serine/threonine protein phosphatase PP1-beta catalytic subunit|serine/threonine-protein phosphatase PP1-beta catalytic subunit
Swissprots	B2R5V4 P37140 Q6FG45 Q5U087 P62140 D6W565
Accessions	AAA85093 AAY24124 EAX00527 EAX00528 EAX00529 EAX00530 P62140 AF092905 AAF01137 AI147919 AK295957 BAG58737 AK303682 BAG64675 AK312329 BAG35251 AK316532 BAH14903 AM392772 CAL37650 BC002697 AAH02697 BC012045 AAH12045 BE047402 BI551898 BM835970 BQ933435 BT019744 AAV38549 BU740022 BX477003 BX647295 BX647970 CB111140 CD656807 CD722576 CR542263 CAG47059 CR542285 CAG47080 EU668339 ACF94492 X80910 CAA56870 NM_002709 NP_002700 NM_206876 NP_996759 NM_206877
Function	Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T- cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). {ECO:
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11739654}. Nucleus {ECO:0000269|PubMed:11739654}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11739654}. Nucleus, nucleolus {ECO:0000269|PubMed:11739654}. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
Top Pathways	Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PP1β CRISPR/Cas9 KO Plasmid (h) - sc-402145 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1β HDR Plasmid (h) - sc-402145-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1β Double Nickase Plasmid (h) - sc-402145-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1β Double Nickase Plasmid (h2) - sc-402145-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1β CRISPR Activation Plasmid (h) - sc-402145-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1β CRISPR Activation Plasmid (h2) - sc-402145-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1β Lentiviral Activation Particles (h) - sc-402145-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1β Lentiviral Activation Particles (h2) - sc-402145-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PP1β siRNA (h) - sc-36295 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PP1β shRNA Plasmid (h) - sc-36295-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PP1β shRNA (h) Lentiviral Particles - sc-36295-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Protein Phosphatase 1 beta RNAi - H00005500-R05 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Protein Phosphatase 1 beta RNAi - H00005500-R06 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® Human Phosphatase - SIHP1023 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0516 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP1024 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0515 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0514 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP1022 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN17255 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17255 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

PPP1CB siRNA (Human) - CRH3685 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Protein Phosphatase 1 beta RNAi - H00005500-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human PPP1CB (NM_002709.2) - SHH380960 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PPP1CB(NM_002709.2) - SHR132648 from Creative biogene Category siRNA Species Reactivities Human

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