MTAP

Gene Symbol	MTAP
Entrez Gene	4507
Alt Symbol	BDMF, DMSFH, DMSMFH, HEL-249, LGMBF, MSAP, c86fus
Species	Human
Gene Type	protein-coding
Description	methylthioadenosine phosphorylase
Other Description	5'-methylthioadenosine phosphorylase|MTA phosphorylase|MTAPase|MeSAdo phosphorylase|S-methyl-5'-thioadenosine phosphorylase|epididymis luminal protein 249
Swissprots	Q5T3P3 Q9H010 I2G7M5 I2G7N0 I2G7M7 I2G7M9 Q13126 I2G7M8 I2G7M6
Accessions	AAR24607 BAD60918 EAW58605 EAW58606 Q13126 AB062485 BAB93510 AF109294 AAD19641 AF216650 AAF82688 AK024734 AK300592 BAG62290 AK309365 AY712791 AAU04442 BC012316 AAH12316 BC018625 AAH18625 BC026106 AAH26106 BG576334 BM994282 BQ220538 BQ232183 CA440131 CR541670 CAG46471 CR541710 CAG46511 FJ224338 ACI46030 HE654772 CCF77345 HE654773 CCF77346 HE654774 CCF77347 HE654775 CCF77348 HE654776 CCF77349 HE654777 CCF77350 JF432462 ADZ15679 L40432 AAG38871 U22233 AAA81646 NM_002451 NP_002442
Function	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. {ECO:0000255|HAMAP-Rule:MF_03155, ECO:0000269|PubMed:3091600}.
Subcellular Location	Cytoplasm. Nucleus {ECO:0000255|HAMAP- Rule:MF_03155}.
Tissue Specificity	Ubiquitously expressed.
Top Pathways	Cysteine and methionine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® MTAP siRNA I - 6284 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® MTAP siRNA II - 6285 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

MTAP CRISPR/Cas9 KO Plasmid (h) - sc-406223 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MTAP HDR Plasmid (h) - sc-406223-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MTAP Double Nickase Plasmid (h) - sc-406223-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MTAP Double Nickase Plasmid (h2) - sc-406223-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MTAP CRISPR Activation Plasmid (h) - sc-406223-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MTAP CRISPR Activation Plasmid (h2) - sc-406223-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MTAP Lentiviral Activation Particles (h) - sc-406223-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MTAP Lentiviral Activation Particles (h2) - sc-406223-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MTAP siRNA (h) - sc-60006 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MTAP shRNA Plasmid (h) - sc-60006-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MTAP shRNA (h) Lentiviral Particles - sc-60006-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU087431 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14687 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14687 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MTAP siRNA (Human) - CRH2991 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MTAP RNAi - H00004507-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human MTAP (NM_002451.3) - SHH346088 from Creative biogene Category siRNA Species Reactivities Human

MTAP shRNA Plasmid (Human) - CHH2991 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

MTAP miRNA 3'UTR clone - MiUTR1H-06498 from Creative biogene Species Reactivities Human

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